Rafael Rosell, Niki Karachaliou


It is a great honor to serve as Guest Editors for these issues of Translational Lung Cancer Research devoted to lung cancer. In 1949, in Cancer, Karnofsky published the first study on the treatment of lung cancer with nitrogen mustard. Response rates were observed in plain chest X-rays, and the improvement of symptoms was scored from + to +++. After more than 60 years, lung cancer remains an incurable disease, with a five-year survival of around 4% in metastatic disease.