Lung cancer is the leading cause of cancer mortality worldwide. In 2012, it is estimated that there were 1.825 million new cases diagnosed globally (1). The majority (85–90%) of lung cancer cases are of non-small cell histology. Approximately 30% of non-small cell lung cancer (NSCLC) patients present with locally advanced disease. Surgery plays a minor role in this group and radiotherapy combined with chemotherapy is the treatment of choice for the majority of patients (2,3). Outcome is poor (~15–30% 5-year survival) (4,5) and has changed little over the last few decades, highlighting the urgent need for research to improve treatment efficacy. In recent years clinical trials have investigated the role of improving the radiotherapy therapeutic ratio by improving accuracy and by treatment intensification with altered fractionation, dose escalation and concurrent systemic therapy (3). The integration of new technology into the radiotherapy pathway has the potential to provide further patient benefit by facilitating personalization of treatment, thereby enabling individualised treatment intensification. An example is the integration of thoracic MRI with a linear accelerator (MR-Linac) (6).
For the majority of patients with lung cancer, thoracic MRI has been of limited value due a number of factors including the low tissue density of lung parenchyma with resultant poor signal-to-noise ratio and the presence of respiratory and cardiac motion (7). However, the Atlantic MR-Linac Consortium group, which represents a collaboration of seven international research centres, is working to overcome these issues and bring these techniques into an adaptive radiotherapy workflow (Figure 1). MRI can potentially be used at various points in the radiotherapy pathway from disease staging and patient selection, target and organ at risk (OAR) delineation, image-guided adaptive treatment delivery through to assessment of treatment response. With potential for incremental gains at each of these stages in the radiotherapy pathway, MR image-guided and adaptive radiotherapy treatments may provide a platform for individualized treatment intensification in lung cancer patients.
This review discusses recent developments and limitations of the current radical lung radiotherapy pathway and gives an overview of available MRI technology, challenges for the introduction of MRI into the lung radiotherapy workflow and opportunities for research translating into potential clinical benefits.
Searching strategy and selection criteria
References were identified through PubMed search using terms which included ‘lung cancer radiotherapy’, ‘lung cancer MRI’, ‘MR-Linac’ from January 1986 until April 2017. Reference lists of included studies were hand-searched to identify missing publications. Only papers in English were reviewed. All authors agreed on the final selection of references based on relevance to this review.
Disease staging and patient selection
Accurate disease staging of lung cancer facilitates treatment decisions and guides prognosis. Modern curative-intent radiotherapy trials mandate that patients have an up-to-date whole body F-18 fluorodeoxyglucose position emission tomography (F-18-FDG PET) computerized tomography (CT) scan which has been shown to be superior to CT or F-18-FDG PET alone in primary tumour staging (8,9). F-18-FDG PET has high sensitivity for the evaluation of solitary pulmonary nodules, intra-thoracic pathological lymph nodes and distant metastatic disease (10).
Traditionally, thoracic MRI imaging has had limited use in routine lung cancer disease staging. However due to superior soft-tissue contrast compared to CT and 18-FDG PET-CT, MRI can be helpful to assess for mediastinal or chest wall invasion (11,12). The National Institute of Clinical Excellence (NICE), National Comprehensive Cancer Network (NCCN) and American College of Chest Physician (ACCP) guidelines advocate the use of MRI in particular to assess disease resectability of superior sulcus tumours (13-15) (Table 1). There is limited evidence for MRI in the primary tumour (T) staging in other lung tumour locations, but research is ongoing (Figure 2). At present, NICE guidelines specifically state that MRI ‘should not routinely be performed’ to assist disease staging outside the situation of superior sulcus tumours or suspected chest wall invasion (13). The use of MRI for the evaluation of solitary pulmonary nodules is reviewed elsewhere (9).
When considering MRI for nodal (N) staging of thoracic malignancies, published data are variable. Interpretation of 3 meta-analysis (Table 1), are limited by variations in individual trial’s diagnostic criteria and differing MRI pulse sequences, resulting in changes in pooled sensitivity and specificity. Furthermore some individual trials are included in more than one meta-analysis. However, despite these limitations, the data suggest that diffusion weighted (DW) MRI has a high specificity (up to 0.72; 95% CI: 0.63–0.80) for N staging of NSCLC (19-21) (Table 1). All studies highlight the need for standardization of diagnostic criteria before a general recommendation for using DW-MRI in routine clinical practice in the diagnosis of pathological lymph nodes can be made (21,24). Following consensus on standardization of diagnostic criteria, further methodological testing is required, preferentially within large multi-institution trials, in order to move closer to the possible adoption of these promising techniques into a regular clinical workflow (Table 1) (24).
With regards to staging for metastatic (M) disease, the principal role for MRI has been in the detection of brain metastasis. However, there is an increasing body of evidence advocating the use of whole body MRI, which has become feasible following adoption of fast acquisitions, for assessment of metastatic disease (25,26). One study comparing 3.0 Tesla (T) whole body MRI with 18-FDG PET-CT in 165 NSCLC patients showed no statistically significant difference in accuracy of staging between imaging modalities. However, whole body MRI was more effective for detecting brain (five true-positive cases with whole body MRI and one with PET-CT) and liver metastasis (four true-positive cases with MRI and zero with PET/CT, but three false positive cases with MRI). Conversely, data from the same small patient cohort, suggested 18-FDG PET-CT may be more useful for detecting distant lymph node and soft-tissue disease (22), but this work needs further validation in larger patient cohorts. The superiority of MRI in detection of brain and hepatic metastases, in comparison to 18-FDG PET-CT, has been attributed to physiological FDG update in these organs which may impede metastatic disease visualization in PET and the improved soft tissue contrast with MRI (9). A further development has been the introduction of co-registered 18-FDG PET-MRI imaging. When compared to 18-FDG PET-CT, the hybrid 18-FDG PET-MRI system potentially offers the addition of improved soft tissue contrast, with less radiation exposure (27), and early data are encouraging (Table 1) (23), but further work investigating novel tracers and incorporating motion is required (9).
MRI avoids many of the shortcomings and disadvantages of PET imaging for staging, including the logistics of radiotracer synthesis and transport; the accuracy of standardized uptake variables (SUV) measurement which can be affected by blood glucose levels; partial-volume averaging effect; recovery coefficient and radiation exposure (28). However, most of the evidence underpinning the utility of thoracic MRI for staging is in its infancy, based on small patient numbers. Further research should focus on investigating potential solutions to overcome thoracic MRI challenges (Table 2) within carefully designed multicenter studies. It is envisioned that future imaging developments may potentially expand the role of MRI in staging lung cancer patients.
Target and OAR delineation
Accurate imaging of target and normal tissue is essential for radiotherapy planning. Baseline planning CT scans form the foundation on which the target and OAR are delineated and dose-volume metrics are generated. Inaccuracies at this stage of the pathway carry through to all subsequent stages.
For thoracic radiotherapy, the OAR to be delineated include the lungs, oesophagus, heart, spinal cord and for certain patients the brachial plexus, trachea, main bronchi, major vessels and chest wall. Inter and intra-observer variations in OAR delineation are reported (Table 3) and although the use of a thoracic CT OAR atlas has led to improved delineation reproducibility of the oesophagus and heart (38), there remains room for improvement. With regards to brachial plexus contouring, in their atlas Kong et al. state that ‘contouring the brachial plexus on CT scans is challenging’ (39) and instead recommend CT-MRI fusion in situations when it is necessary to determine the location of the brachial plexus. In addition, it is anticipated that OAR such as the oesophagus and heart, which even with the use of an atlas are subject to CT delineation variability (Table 3), will be more consistently delineated with the addition of MRI (Figure 3). For the heart in particular, there is growing interest in quantifying radiation exposure to cardiac sub-structures (40-42) given the correlation of cardiac dose with overall survival following radical radiotherapy for lung cancer (41,43).
Incorporation of F-18-FDG PET-CT imaging into radiotherapy treatment planning has resulted in improvements in the reproducibility of delineating lung targets (8,10). An important study comparing delineation variability between 11 clinicians showed that with the addition of a free-breathing F-18-FDG PET, inter-observer variation in target delineation was reduced from a standard deviation of 1.0 cm with CT alone to 0.4 cm with the addition of PET (44). For delineation of the tumour target, MRI offers superior spatial resolution to PET imaging (45). The benefits of integrating MRI into the radiotherapy planning pathway for the delineation of targets in the head and neck, central nervous system and pelvis have already been established (46-50). However, there are limited published data from comparable studies in patients with lung cancer due to challenges relating to the development of suitable thoracic MRI sequences. Nevertheless, a clinical need exists, particularly for tumours invading the mediastinum or abutting parenchymal lung changes (e.g., distal collapse/consolidation) where accurate disease extent assessment remains challenging. Improvement in the evaluation of the risk of large mediastinal blood vessel invasion (e.g., aorta and pulmonary arteries) is also required for the assessment of the risk of acute severe bleeding during radiotherapy. The international Atlantic MR-Linac Consortium group is currently working to optimize thoracic images for radiotherapy planning (Figure 3). Another consideration for thoracic OAR and target delineation is respiratory motion. Over the years, various techniques have been developed to assess and account for target motion (51) with the most widely adopted motion evaluation technique being a respiratory-correlated or 4D CT scan. The information on target motion can be used to create an individualized motion-encompassing target volume (51). There have been recent advances in development of respiratory-correlated 18-FDG PET-CT scans, and ongoing studies are investigating the clinical utility of 4D 18-FDG PET-CT for radiotherapy planning (8), however it is not routinely used in standard clinical practice. The development of 4D MRI images for radiotherapy (Table 2) remains challenging (32,52,53). 4D MRI has the potential to provide high spatial resolution information for creation of motion-managed treatment plans (53,54) (for example, using an internal target volume or mid-position approach) (55). A research focus of the Atlantic MR-Linac consortium is the development of geometrically accurate thoracic MRI sequences for optimal OAR and target visualization to improve the reproducibility of delineation in the presence of respiratory motion.
The aim of treatment planning is to attain conformity of planned dose to target volume whilst minimizing dose to surrounding normal tissue. Following the identification and contouring of the target, margins are added to account for microscopic disease extension [clinical target volume (CTV)], and setup and delivery uncertainties [planning target volume (PTV)] with inherent uncertainties and inaccuracies with this process. Historically the gross tumour volume (GTV) to CTV margins were generated based on population data from analysis of pathological specimens (56). Standard population based CTV-PTV margins vary between institutions, reflecting the differences in set-up techniques, imaging frequency and verification strategy (57,58).
MRI has the potential to alter our approach to radiotherapy planning. Research studies that correlate MRI findings with pathology specimens are required to investigate whether GTV-CTV margins for the primary tumour and lymph nodes can be adjusted. In the meantime, thoracic MRI has the potential to reduce CTV-PTV margins as improved target delineation reproducibility would reduce the systematic error contribution to CTV-PTV margins (59). A recent study suggests that the addition of MR sequences to CT and PET did not lead to reduced observer variability, however commented that this may be due to limited observer experience to date with contouring on MR sequences (60). Furthermore, while other radiotherapy platforms may allow for possibility of margin reduction with treatment adaptation accounting for inter-fraction motion, MR-guided treatment units offer the possibility for additional adaptation based on intra-fractional changes in the target and OAR (61-63). A reduction in treatment margins would enable greater normal-tissue sparing or provide scope for individualized dose escalation based on predefined OAR constraints (isotoxic approach) (64).
Secondly, functional MRI sequences may potentially be used to provide spatial maps of clinically-relevant cancer hallmarks and normal tissue physiology (Figure 4). Information on tumour heterogeneity can be integrated into radiotherapy planning in order to facilitate heterogeneous dose painting, using similar methodologies to ongoing studies boosting the target volume based on FDG-PET imaging (NCT01507428 and NCT01024829) (65,66). Tumour heterogeneity identified on imaging can be exploited as a predictive biomarker to select patients for inclusion in treatment intensification trials. A recent development is the ability to image oxygen deprivation within tumours (hypoxia) with MRI. Hypoxia is an important factor in resistance to radiotherapy and is linked with poor survival in patients with lung cancer (67-69). Blood oxygenation level dependent (BOLD)-MRI has been investigated for this purpose with varying degrees of success due to the imperfect association of perfusion with hypoxia and significant susceptibility to artifacts, respectively (70-72). Oxygen-enhanced (OE)-MRI is a promising technique which depends on quantifying oxygen within plasma and interstitial fluid (73). A respiratory challenge induces immediate and measurable changes in R1 (c.f. R2* in BOLD) (R1 is the relaxation rate of 1/T1 and R2 is 1/T2) according to the degree of tumour oxygenation (74,75). The fraction of tumour refractory to this challenge was recently shown to be a robust biomarker of hypoxia in preclinical models (76) and this technique is currently undergoing early clinical validation in patients with lung cancer (Figure 4). This approach is potentially clinically translatable and avoids several shortcomings associated with hypoxia-specific PET imaging [e.g., complexity of radiotracer manufacture and quality assurance, poor image contrast and the need for patients to wait for extended periods following radiotracer injection prior to imaging (77)]. To date, these factors have hindered integration of hypoxia imaging in clinical trials of radiotherapy dose painting, or hypoxia-targeted therapies.
Thirdly, the implementation of these MR-guided treatment units has implications for treatment planning as the irradiation geometry of MR-guided treatment units deviates from that of conventional linacs. Indeed treatment is delivered within a static magnetic field which can change the path of secondary electrons as a result of the Lorentz force (6,49). The source, orientation and path of each beam and the strength of magnet all result in variations in imaging capability and delivered dose (Table 4). The ViewRay MRIdian system (ViewRay Inc., Oakwood Village, Ohio, USA) combines a split 0.35 Tesla (T) magnet with three cobalt-60 (60Co) sources arranged 120 degrees apart on a single rotating gantry with the aim of maximizing treatment efficiency by delivering simultaneous radiation at different beam angles whilst minimizing beam interference. Planning studies using ViewRay in patients with lung cancer have shown that it is possible to plan clinically deliverable treatments (85-87). In comparison to a conventional linac, when considering SBRT for centrally located early stage disease, 90% of 60Co plans were deemed clinically deliverable by experienced clinicians in comparison to 100% of the linac plans. Moreover all of the 60Co plans resulted in higher dose to OAR than the linac plans, but this was only statistically significant for the low dose to normal lung (87). For patients with locally advanced disease, only limited data are available, but higher mean lung doses have been reported in 60Co plans (85).
Other MR-guided treatment units have been designed which combine a linac with an MRI scanner, again with variations in magnet positioning, strength and orientation (Table 4). The seven members of the Atlantic MR-Linac Consortium have purchased a clinical prototype developed by Elekta and Philips, which combines a 1.5 T wide bore MRI scanner with a 7 MV linear accelerator. This hybrid machine has been purposefully designed with a higher magnetic strength in order to optimize signal-to-noise ratio and thus provide images of diagnostic quality (88). A number of studies have investigated the dosimetric consequences of treating in variable strength magnetic fields in patients with lung cancer (30,31,89). For early stage small tumours planned with an in-line magnet orientation, an increase in MR field strength has been associated with an increase in mean dose enhancement to the GTV (89). In locally advanced disease planned with a perpendicular magnet orientation, increased conformality can be seen when comparing plans in a 1.5 versus zero T magnetic field (unpublished). In regards to OAR dose, comparing zero with 1.5 T magnetic fields, planning studies have suggested a small but statistically significant increase in skin dose with early stage disease (30) and locally advanced disease, together with a small (+0.3 Gy) but statistically significant (P<0.01) increase in dose to distal lung (defined as any healthy lung tissue more than 5 cm from the ITV) on the 1.5 T MR-Linac plans (unpublished). However, all studies demonstrate that it is possible to generate clinically acceptable plans for early and locally advanced lung cancer patients on a 1.5 T MR-Linac. It is anticipated that once the adaptive elements of MR-guided lung treatments are incorporated into the patient workflow this should outweigh the previously observed dosimetric effects of planning within a magnetic field. Pre-clinical and clinical studies investigating the full potential benefit of an adaptive workflow on MR-guided treatment units are required.
At treatment delivery, the objective is consistency between the planned and delivered dose distributions to the target and surrounding normal tissues. Within the last decade, the widespread availability of cone beam CT (CBCT) has provided 3D and 4D images with soft tissue definition of the target volume that can be compared to the planning scan prior to or even during daily treatment delivery. Due to the volumetric nature of CBCT acquisition, the images are subject to a higher degree of scatter and consequently poorer image quality than diagnostic CT, but still provide superior soft tissue information for verification when compared to historical two dimensional (2D) mega-voltage (MV) electronic portal images (EPI) (90). Furthermore, advances in imaging software have permitted rapid acquisition, reconstruction and registration of CBCT images with the planning CT scan, allowing assessment of variation between verification and reference planning images and daily on-line correction of the plan’s isocenter by couch correction. Daily CBCT imaging with on-line tumour match is currently regarded as optimal imaging for both treatment of early stage tumours with stereotactic radiotherapy (91-94) and carina match for locally-advanced tumours with conventionally fractionated treatment (58).
The current CBCT workflow has limitations as centrally placed primary tumours and mediastinal lymph nodes can be hard to identify on CBCT compared to the planning CT scan (Figure 5) with often poor reproducibility of matching (57). Carina or spine matching has been proposed as being most reproducible until a time that soft tissue imaging is improved (57). Furthermore, within the current workflow CBCT only provides imaging prior to treatment delivery rather than at the time of delivery. Therefore, if the patient shifts position between CBCT acquisition and beam-on treatment delivery this will not be accommodated.
By contrast, with superior soft-tissue visualisation, MR-guided treatment units will potentially facilitate direct primary tumour and mediastinal lymph node matching pre-treatment (Figure 5) (95), thus potentially permitting a reduction in the setup component of CTV-PTV margins. Furthermore, with the rapid advancements in 4D MR, where it is now possible in a research capacity to acquire and reconstruct 4D images in less than 5 minutes (96), verification of daily breathing patterns prior to and during treatment may facilitate further personalization of radiotherapy delivery in the future.
Daily treatment plan adaptation
With pre-treatment CBCT, the daily standard workflow relies on optimally adjusting the plan isocentre by couch shift in three translational planes. This approach can only correct for error due to displacement of a consistent target shape and volume and is unable to account for a change in shape and volume of the target between fractions. A further issue is the independent displacement of primary tumour and lymph node targets relative to each other and to OARs (97,98). Differential margins (98) or separate plans and isocentres for primary tumour and lymph node targets may potentially assist, however where matching to central disease and mediastinal lymph nodes is challenging and there is potential for plan overlap, these strategies are not without issues. A study, predominantly of patients with locally advanced lung cancer, evaluated 1,793 CBCT scans and showed intra-thoracic anatomical changes in 72% patients, the most frequently observed change being tumour regression in 35% (61). The changes in normal anatomy observed included 19% of cases exhibiting changes in atelectasis and 6% of cases demonstrated fluctuations in pleural effusion (61). Other studies report a variable reduction in tumour size of 15–71% (62,99). Changes in tumour and normal tissue anatomy during treatment have dosimetric consequences on target and surrounding OARs and this is particularly important where the target abuts a dose limiting OAR. With current CBCT imaging, one approach to the observed intra-thoracic anatomical changes has been with the use of a “Traffic Light Protocol” which has been used for radiographers to trigger clinical or physics reviews based on matching at the time of treatment (61). This approach may be useful to highlight variations for consideration of re-planning but does not provide a daily re-planning solution.
To account for changes in shape, volume and position of the target and surrounding normal tissues on a daily basis, the ability to adapt the treatment plan following daily pre-treatment imaging immediately prior to delivery is attractive. When considering adaptive therapy, it is important to note that although significant anatomical changes can be seen over the course of radical treatment in locally advanced lung cancer, a full comprehension of how to incorporate these changes into adaptive radiotherapy planning is not yet known. A phase 2 trial investigating the concept of reducing target volumes based on CT during treatment for locally advanced NSCLC has recently been published (100). In this study weekly CT planning scans were performed over the course of treatment and in case of tumour shrinkage, a new tumour volume was delineated and a new treatment plan was calculated. The results suggest reduced toxicity and low rate of marginal failures with such an adaptive approach however this work is yet to be validated in larger randomised trials. The envisioned adaptive workflow of the MR-Linac provides potential to investigate this further with repeat imaging on a daily basis, without the need for additional CT scans and the associated concomitant radiation exposure.
Additionally, the workflow may offer the capability for rapid on-line plan adaptation immediately prior to treatment (101). The development and adoption of automated on-line plan adaptation is envisioned to significantly simplify the daily re-planning process. Iterative sequencing over the course of a multi-fraction treatment will ensure optimal dose coverage of the target for minimal dose to OARs is achieved (102). The daily adaptive capability of the MR-Linac may therefore widen the therapeutic window, permitting further safe isotoxic treatment intensification.
Real-time target tracking
Currently, without ‘beam-on’ imaging on a standard linac, actual intra-fraction motion is unable to be taken account of in real-time. For example ‘beam-on’ imaging could be of interest in the case of a patient breathing erratically or if there is variation in the form of baseline respiratory shift or drift. In patients with peripheral early stage tumours baseline drifts of at least 3 mm have been observed in 72% of treatment fractions (103). Adequate safety margins are needed to accommodate these changes and this is taken into consideration in the generation of CTV-PTV margins. Options for intra-fraction motion adaptation remain limited. Internal fiducial markers which have been used for CyberKnife therapy (a robotic radiosurgery system) (104,105), are now also used on the Vero gimballed linac system (106). With both systems real-time tracking of the fiducials permits real-time tracking of the target providing that the fiducials are adequately positioned around or in the target. However, the orthogonal kV imaging required throughout treatment to track the fiducials is associated with additional radiation exposure for the patient. While this is considered clinically acceptable for a short course of hypo-fractionated stereotactic radiotherapy, the additional radiation exposure would be larger for patients having a protracted course of conventionally fractionated radiotherapy for locally advanced disease. Moreover, given the potential for differential motion between the primary tumour target and mediastinal lymph node targets (51) patients with locally advanced disease may require multiple fiducial markers in both the mediastinum and peripheral lung tissue which is both impractical, costly and would expose patients to additional insertion-related risks (107).
‘Real-time imaging’ has two important prerequisites: firstly the imaging must be of high quality and temporal resolution to accurately reflect the underlying anatomy; and secondly the imaging must be gained with sufficient speed so that it gives a true reflection of underlying tumour position (108). With tumour and OAR visualisation during ‘beam-on’ time, the MR-Linac will enable real-time intra-fractional MR-guided radiation therapy to be developed. Dynamic multi-leaf collimator (MLC) based respiratory motion tracking has been shown in planning studies to be dosimetrically beneficial for lung cancer treatment (109), where it facilitates a reduction in treatment margins and enables treatment beam sculpting to variable intra-fraction target changes. Real-time tracking based on MRI has been modelled in a number of different situations (30,110-113) and clinical studies are currently in development. In the context of novel radiotherapy dose-intensification trials, the tracking potential of the MR-Linac presents yet another exciting application of this hybrid machine. Furthermore, where current isotoxic-dose escalation strategies are based on the initial planning scan (114), the envisioned MR-Linac workflow, with real-time intra-fraction monitoring of planned versus delivered dose and the compensation of observed dosimetric differences, may facilitate a move from ‘image-guided’ to ‘dose-guided’ treatment, allowing further refinement of individualization isotoxic dose-escalation.
Early assessment of treatment response
Dynamic-contrast enhanced (DCE)-MRI is a promising functional MRI technique which has the potential to be both a non-invasive imaging biomarker of tumour response and of early normal tissue toxicity. Kinetic parameters of capillary permeability (e.g., Ktrans) are consistently linked with tumour response to radiotherapy in rectal (115), head and neck (116) and cervical cancer (117) but the data in lung cancer are mixed (118-121), with ongoing studies continuing to investigate the potential of this technique (122). For assessment of underlying OAR function, post-operative forced expiratory volume in 1 second can be estimated from pre-operative pulmonary perfusion imaging using DCE-MRI in patients with lung cancer (123). Furthermore, kinetic changes of DCE-MRI have been shown to differentiate between early radiation pneumonitis and late radiation fibrosis (124).
These applications may improve diagnostic discriminative capacity and therefore management, not only following completion of a course of radiotherapy, but also daily throughout a course of treatment with images acquired on the MR-Linac. A study of functional tumour changes on PET CT during radical radiotherapy for lung cancer has demonstrated that the metabolic tumour volume on PET reduces more than the tumour volume visible on CT during the treatment course (125). Results from a single arm trial, published recently, confirm dose escalation to the target with adaptation based on metabolic changes once during treatment after approximately two thirds of the total dose provides favorable local disease control (126). The RTOG 1106 randomized trial using adaptation based on PET is ongoing (NCT01507428). Feasibly, regular (up to daily) functional imaging sequences, taken in the treatment position after treatment just prior to a patient getting off the couch (post-beam images), may facilitate treatment adaptation based on functional changes during a course of therapy, in a similar way to the RTOG 1106 trial. In addition, post-beam functional imaging may also enable adaptation based on probability of normal tissue toxicity, for example early markers of toxicity could be used as a selection criterion for potential tolerability of treatment intensification. However, optimal integration of novel functional MRI sequences with more established functional imaging such as F-18-FDG PET remains to be defined and warrants further studies including correlation of image findings with pathology (45).
Despite being in its infancy, the integration of MRI into the radiotherapy treatment pathway holds undeniable promise for patients with lung cancer with the scope of providing individualized incremental benefits, strengthening each link in the treatment workflow. It is envisioned that more accurate disease staging and patient selection for radical treatment will be followed by more reproducible tumour target and OAR delineation. This will allow treatment plans to be generated with smaller treatment margins. With the potential for daily plan adaptation immediately prior to treatment to take account of inter-fraction changes and for development of real-time image-guided and even dose-guided treatment to take account of intra-fractions changes, further gains in the therapeutic index may be made. Additional functional imaging acquired regularly during the course of treatment may provide pivotal information about biological tumour characteristics and normal tissue toxicity, potentially guiding treatment adaptation radiotherapy for further clinical gains.
The technical complexities (Table 2) that need to be overcome prior to clinical implication at each step remain an area of active research for members of the Atlantic MR-Linac Consortium and other research groups. Carefully designed multi-centre pre-clinical and clinical studies are required to demonstrate improvement in local disease control and overall survival for these patients.
Prof. Faivre-Finn and Dr. McDonald gratefully acknowledge the support of the NIHR Biomedical Research Centre and the CRUK ARTNET Network. Prof. Faivre-Finn gratefully acknowledges the CRUK Major Centre. All authors gratefully acknowledge the support of Elekta and Philips to the Altantic MR-Linac consortium.
Conflicts of Interest: The authors have no conflicts of interest to declare.
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