Development of biomarkers for real precision medicine

Masahiro Shibata, Mohammad Obaidul Hoque

Abstract

Most cancers are genetically heterogeneous diseases, and many genes or gene products have altered their expressions or activities in cancer cells due to a variety of genetic and epigenetic mechanisms in DNA. Copy number aberrations (CNAs), common genomic events during carcinogenesis, are known to affect a large fraction of genome and extensively studied for last several decades.