Article Abstract

Development of biomarkers for real precision medicine

Authors: Masahiro Shibata, Mohammad Obaidul Hoque


Most cancers are genetically heterogeneous diseases, and many genes or gene products have altered their expressions or activities in cancer cells due to a variety of genetic and epigenetic mechanisms in DNA. Copy number aberrations (CNAs), common genomic events during carcinogenesis, are known to affect a large fraction of genome and extensively studied for last several decades.