Osimertinib in first line setting: for Asian patients

Keisuke Onoi, Yoshiko Kaneko, Junji Uchino


The discovery of the epidermal growth factor receptor (EGFR) gene as the first driver gene in lung cancer has led to a major paradigm shift in lung cancer treatment. Gefitinib and other EGFR-tyrosine kinase inhibitors (TKIs) have demonstrated excellent antitumor activity against EGFR mutation-positive non-small cell lung cancer (NSCLC). However, resistance to TKI emerged over the course of treatment, and resistance due to T790M mutations was noted in approximately half of the cases (1,2).