Article Abstract

Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

Authors: Daniel B. Costa


Lung cancers are heterogeneous tumors often characterized by mutations in oncogenes and tumor suppressor genes. Anaplastic lymphoma kinase (ALK) genomic aberrations were first identified in non-small cell lung cancer (NSCLC) in 2007 (1). We now know that a substantial fraction (approximately 5%) of all NSCLCs harbor rearrangements between ALK and fusion partners (such as EML4, TFG, KIF5B, KLC1 among others).