P30. Ki-67 expression in lung carcinoid tumors
CELCC 2014 Abstracts

P30. Ki-67 expression in lung carcinoid tumors

Bernard Budimir1, Suzana Kukulj1, Luka Brcic2, Luka Opasic2, Branka Cucevic1, Marina Serdarevic1, Gordana Drpa1, Slavica Sovic3

1University Clinic for Lung Disease Jordanovac, KBC Zagreb, Zagreb, Croatia; 2University of Zagreb School of Medicine, Institute of Pathology, Zagreb, Croatia; 3University of Zagreb School of Medicine, School of Public Health, Zagreb, Croatia


Background: Ki-67 is nuclear protein with essential role in the control and timing of cell proliferation, largely studied in neuroendocrine tumors, but yet without clear clinical implications. A difference of percentage of Ki-67 labeling index (LI) was observed in different neuroendocrine tumors. This study intended to determine difference of Ki-67 LI between typical (TC) and atypical lung carcinoid (AC) using imunohistochemical methods, and to correlate clinical parameters with percentage of Ki-67 LI in TC and AC.

Methods and participants: A total of 49 specimens of TC and AC between year 2007 and 2009 were retrieved from our archive. Minimum follow-up period was 5 years. The clinical parameters included age, gender, tumor size, node and metastasis stage, recurrence of disease, therapy and overall survival (OS). Ki-67 was evaluated in the areas of highest positivity, and expressed as percentage of 400 tumor cells.

Results: Median value Ki-67 LI for atypical carcinoid was 17.1 (min 1.5, max 61.5). Median value Ki-67 LI for typical carcinoid was 3.8 (min 0.3, max 16). Although there is statistical difference in an average tumor size between AC and TC (P=0.02), there was no correlation between tumor size and Ki-67 expression. There was statistical difference between AC and TC concerning recurrence/metastatic disease (P=0.01) and OS (P=0.004), but none is in any relation with Ki-67 LI. The 5-year OS for typical carcinoid is 97.4% (95% CI: 97.3-97.5). The 5-year OS for atypical carcinoid is 60% (95% CI: 30-90).

Conclusions: Our study showed that Ki-67 LI was useful in dividing TC and AC, which is in concordance with published data. We also demonstrated that lower Ki-67 LI correlated with survival of the patients, regardless of carcinoid type. This study did not show any significant difference between AC and TC and Ki-67 LI in regards with age, gender, tumor size, recurrence/metastatic disease, therapy and overall survival, probably because small number of participants.

Keywords: Carcinoid; Ki-67


doi: 10.3978/j.issn.2218-6751.2014.AB042


Cite this article as: Budimir B, Kukulj S, Brcic L, Opasic L, Cucevic B, Serdarevic M, Drpa G, Sovic S. Ki-67 expression in lung carcinoid tumors. Transl Lung Cancer Res 2014;3(5):AB042. doi: 10.3978/j.issn.2218-6751.2014.AB042

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