Cons: long-term CT-scan follow-up is not the standard of care in patients curatively treated for an early stage non-small cell lung cancer
Controversies on Lung Cancer: Pros and Cons

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Cons: long-term CT-scan follow-up is not the standard of care in patients curatively treated for an early stage non-small cell lung cancer

Jan P. van Meerbeeck, Halil Sirimsi

Thoracic Oncology, MOCA, University Hospital Antwerp, Belgium

Correspondence to: Jan P. van Meerbeeck. Thoracic Oncology, MOCA, University Hospital Antwerp, Belgium. Email: jan.van.meerbeeck@uza.be.

Submitted Jun 05, 2015. Accepted for publication Jun 30, 2015.

doi: 10.3978/j.issn.2218-6751.2015.07.06


Introduction

About 25% of patients with early stage (I, II, IIIA non-N2) non-small cell lung cancer (NSCLC) qualify for a treatment with curative intent, consisting of either radical surgical resection or radical radiotherapy. The former consists of at least an anatomical lobectomy, the latter is nowadays mainly given at ablative doses with stereotactic techniques (SABR). Radically treated patients may develop either locally or distantly relapsing lung cancer, or a second primary (lung) cancer. Besides, they retain a significant excess conditional mortality with an increasing relative contribution of cardiovascular and respiratory co-morbidity (1). Recurrence dynamics of resected early-stage NSCLC displays a multi-peak pattern, which supports the hypothesis of a metastasis growth model previously described for early-stage breast cancer (2). An initial surge in the hazard rate 9 months after surgery, is followed by two smaller peaks at the end of the second and fourth years, respectively (Figure 1). This pattern is dominated by distant metastatic events which decrease over time and are virtually absent after 5 years. Two distinguishable peaks are noted for local recurrence in the first and second years, but this is rare thereafter. The risk of local or distant recurrence is 10-38%, mainly dependent of stage and highest in pII-III NSCLC. This risk can be moderately reduced by the administration of postoperative platinum-based chemotherapy, with an average increase in 5-year survival of 5% (3). In contrast, the hazard rate for second primary lung cancer exhibits a more uniform pattern over time, is 1% to 4% per patient per year in most series (4) and increases even after 5 years. The median time interval between the two tumours is 14.5 months (5,6). Lastly, these patients are at risk of developing a second primary non-respiratory cancer: the most frequently diagnosed tumours are located in the head and neck and the urinary tract.

Figure 1 Cause-specific hazard rate estimates for local recurrence, distant metastasis, and second primary in 1,506 patients undergoing surgery with curative intent for early-stage non-small-cell lung cancer [copyright with permission of (2)]. Hazard rate obtained by the piecewise exponential regression approach. Vertical lines represent 95% pointwise confidence intervals.

The outcome of recurrent lung cancer depends on the type of recurrence, its stage at diagnosis and residual functional treatment capacity. The stage of a second primary lung cancer is the strongest predictor of survival (7). Whereas the treatment of distant metastatic disease is palliative, some patients with loco-regional recurrence or second primary cancer benefit from a second curative treatment, either by resection or by SABR. This is highly dependent of the residual pulmonary function after the first treatment and cardiac co-morbidity. Only a fraction of patients with early stage recurrence are hence benefiting from a surveillance strategy.

Using a systematic postoperative surveillance protocol using CT and chest X-ray (CXR) over a 5-year period, 19 second primary lung cancers were diagnosed among 124 patients who had undergone previous resection, of whom 74% underwent a curative second resection (8,9). The 5-year survival of patients undergoing a reoperation for a second primary was between 25-60% (10-12) (Table 1). Only 1 of 9 isolated local recurrences was resectable, even though 8 of 9 recurrences were asymptomatic at the time of detection. Voltolini et al. reported that 5-year survival after reoperation for locally recurrent bronchogenic carcinoma was 15.5% (10). The 5-year post-recurrence survival in another series of patients undergoing reoperation after local recurrence was also 15% (13). In resected stage I NSCLC with local recurrence, a second surgical resection had a more favourable survival [hazard ratio (HR) 0.089)] than with chemotherapy and/or radiotherapy (HR 0.326) and without treatment (HR 1.0, reference; P = 0.001) (6,14). In early stages of recurrent or secondary lung carcinoma, even higher local control and overall survival rates can be achieved by complete pneumonectomy, with 5-year survival of about 50% in stage I and 40% in stage II carcinoma (15).

Table 1
Table 1 5-year survival after a new resection due to recurrence after complete curative resection of non-small cell lung cancer
Full table

Short term surveillance after radical lung cancer treatment

Opinions differ and evidence is only moderately strong regarding the intensity and duration of surveillance strategy in the first years after a radical treatment. Resection rates for local-only initial recurrence of 33% and 70% are reported using CT for surveillance compared with 37.5% using CXR. Other series report resection rates for metachronous tumors of 63% and 75% using surveillance by CXR. Table 2 lists the available guidelines and recommendations with their grade of evidence. Some recommendations even change grade without proper new evidence, reflecting their expert’s rather than evidence-based decision process. Whereas most guidelines agree on periodical history, physical exam and CXR, variation is present on the frequency of chest CT-scan, varying from none over 4 monthly to yearly for life. We know that CT-scan is superior to CXR in the follow-up of patients after curative resection of lung cancer (22). Recurrences at the post-resection site were detected by CT-scan with a 94% sensitivity and 87% specificity, and a negative predictive value of 99%. Positive predictive value was only 53%. The abovementioned variation in surveillance intensity can be explained by differences in the reported outcomes, varying from detection of early recurrence over resectability, outcome and toxicity or complications of treatment. For second primary lung cancer, a better 5-year survival rate was reported in patients in whom a CT-scan surveillance was installed (18). In a retrospective cohort study using Surveillance, Epidemiology and End Results (SEER)-Medicare data to determine the imaging study used between 90-365 days following surgical resection in stage I-IIIA NSCLC between 1998 and 2009, the comparative effectiveness of CT-scan vs. CXR surveillance was explored in terms of overall survival (OS), using a stratified Cox model based on stage and adjusted for age, gender, race, census median income, Charlson comorbidity index, and adjuvant chemotherapy (23): 5,968 (54%) patients were followed by CT, and 5,083 (46%) by CXR. Patients with earlier stage, older age, and lower census median income were less likely to undergo CT surveillance. CT surveillance increased over the study period from 23% in 1998 to 68% in 2009. In the analysis of surveillance modality and OS, a significant interaction was identified between imaging and diagnosis year (P<0.001). The effect of CT surveillance on OS steadily improved over time, and was significantly better than CXR in the most recent time periods of study.

Table 2
Table 2 Guidelines on surveillance after curative resection
Full table

The schedule of follow up should be ideally modelled to cluster follow-up visits within recurrence peaks at 9 months, 2 and 4 years, to detect events at a time when they may be treated with curative intent (2). Most series do not report on quality of life or other patient-related outcomes. Walsh et al. illustrated that screening for asymptomatic recurrent lung cancer is unlikely to be cost effective (6). A French randomized study is currently addressing the issue of the intensity of surveillance during the first years post radical treatment (clintrials.gov NCT00198341). Pending these results, it is probably best to have at least one chest CT-scan performed within the first postoperative year in patients considered fit for further radical treatment.


Long term surveillance after radical lung cancer treatment

The issue whether surveillance should arbitrarily stop 5 years after treatment is increasingly challenged by recent data on lung cancer screening by low dose spiral CT-scan in a risk population of (ex-)smokers (24). Low-dose CT-scan seems to be comparable to standard-dose CT with regard to the identification of recurrent disease. The National Lung cancer Screening Trialists (NLST) found a 20 percent lower lung cancer mortality among trial participants screened with low-dose helical CT relative to CXR. In the randomized NELSON lung cancer screening trial using low dose spiral CT-scan, 5-year lung cancer survivors are eligible for enrolment in view of their increased risk of second primary lung cancer (25). Data on the prevalence of participants with a second primary cancer and their outcome are awaited.

Long term follow up of curatively treated early lung cancer patients is increasingly becoming an issue now that CT-scan screening will detect more patients in an early stage in whom survival is high and who are, independently of their smoking status, at risk of developing a second primary lung cancer 5 or more years after their first one. Although the data of the NLST are compelling and invite to implementation to the population of radically treated patients, several caveats argue against blind extrapolation:

  • NLST and NELSON participants had to be eligible for radical resection. Increasing comorbidity and functional impairment by a previous resection will render patients less fit for surgery. Although SABR or sublobar resections could replace the standard anatomical lobectomy in lesser fit patients, their equivalence is still debated (26,27);
  • Cost effectiveness (CE) of lung cancer screening in a risk population is estimated to be 81,000 $/QALY with the number of CT-scan being the main cost driver (28). As the incidence of non-calcified nodules in the population of radically treated NSCLC is likely higher than in the NLST, the number of confirmatory conventional dose CT-scan will be higher, negatively influencing the CE balance;
  • Other drivers of CE of screening with low dose spiral CT are age, smoking status and gender. It is unclear whether the population of radically treated NSCLC will match with the NELSON and NLST population for these characteristics, making assumptions about the non-inferiority of low-dose CT-scan in survivors of lung cancer unlikely;
  • How the CT-scan is interpreted also will have an effect. For instance, if radiologists use the new American College of Radiology Lung RADS reporting system, the false positivity rate will decrease by about 50% and could substantially decrease the number of follow-up CT-scan required, at the cost of sensitivity (29);
  • We should be aware that not all screen detected lung cancers are in an early stage. A screening CT-scan looks for non-calcified pulmonary nodules in an asymptomatic at risk population while a diagnostic CT-scan is performed in a person who has a sign or symptom of disease. There is also the risk of unnecessary invasive studies and therapy for “overdiagnosed” lung cancer. Observational studies of screening for lung cancer with low-dose CT that preceded the NLST trial have estimated the extent of overdiagnosis to range between 13 and 27 percent (30,31).

Conclusions

Pending the answers to these questions, it is hap hazardous to embark on a routine follow-up with low dose CT-scan beyond 5 years in all radically treated lung cancer patients. We recommend an international effort to draft and accrue participants in a large scale randomized trial comparing long term surveillance with periodic low dose spiral CT-scan versus a to be agreed standard follow-up, which could consist in simple follow up with or without CXR.


Acknowledgements

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.


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Cite this article as: van Meerbeeck JP, Sirimsi H. Cons: long-term CT-scan follow-up is not the standard of care in patients curatively treated for an early stage non-small cell lung cancer. Transl Lung Cancer Res 2015;4(4):479-483. doi: 10.3978/j.issn.2218-6751.2015.07.06