This issue of Translational Lung Cancer Research (TLCR) focuses on the rapid, changing landscape of lung cancer treatment. The topics of these reviews focus on some of the most important aspects in lung cancer patient care that we feel healthcare providers should be fully aware of. We hope the articles in this issue highlight some of the many advances in lung cancer testing, treatment, and management of toxicities that we have seen over the recent years. We also hope that we have provided a glimpse into what is on the horizon. The renaissance of lung cancer has begun and offers more hope for providers and patients.