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Usefulness of circulating free DNA for monitoring epidermal growth factor receptor mutations in advanced non-small cell lung cancer patients: a case report

  
@article{TLCR10202,
	author = {Clara Mayo de las Casas and Maria Gonzalez-Cao and Santiago Viteri Ramirez and Nuria Jordana Ariza and Ariadna Balada and Mónica Garzón and Cristina Teixidó and Niki Karachaliou and Daniela Morales-Espinosa and Miguel Ángel Molina-Vila and Rafael Rosell},
	title = {Usefulness of circulating free DNA for monitoring epidermal growth factor receptor mutations in advanced non-small cell lung cancer patients: a case report},
	journal = {Translational Lung Cancer Research},
	volume = {5},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Genomic analysis of circulating tumor DNA (ctDNA) released from cancer cells into the bloodstream has been proposed as a useful method to capture dynamic changes during the course of the disease. In particular, the ability to monitor epidermal growth factor receptor (EGFR) mutation status in cell-free circulating DNA (cfDNA) isolated from advanced non-small cell lung cancer (NSCLC) patients EGFR can help to the correct management of the disease and overcome the challenges associated with tumor heterogeneity and insufficient biopsied material to perform key molecular diagnosis. Here, we report a case of long term monitorization of EGFR mutation status in cfDNA from peripheral blood in an NSCLC patient in, with excellent correlation with clinical evolution.},
	issn = {2226-4477},	url = {http://tlcr.amegroups.com/article/view/10202}
}