TY - JOUR AU - Zhan, Ping AU - Zhu, Qing-Qing AU - Miu, Ying-Ying AU - Liu, Ya-Fang AU - Wang, Xiao-Xia AU - Zhou, Ze-Jun AU - Jin, Jia-Jia AU - Li, Qian AU - Sasada, Shinji AU - Izumo, Takehiro AU - Tu, Chih-Yen AU - Cheng, Wen-Chien AU - Evison, Matthew AU - Lv, Tang-Feng AU - Song, Yong AU - AME Lung Cancer Collaborative Group, written on behalf of the PY - 2017 TI - Comparison between endobronchial ultrasound-guided transbronchial biopsy and CT-guided transthoracic lung biopsy for the diagnosis of peripheral lung cancer: a systematic review and meta-analysis JF - Translational Lung Cancer Research; Vol 6, No 1 (February 28, 2017): Translational Lung Cancer Research (Small Pulmonary Nodules) Y2 - 2017 KW - N2 - Background: With the release of the National Lung Screening Trial results, the detection of peripheral pulmonary lesions (PPLs) is likely to increase. Computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and radial probe endobronchial ultrasound (r-EBUS)-guided transbronchial lung biopsy (TBLB) are recommended for tissue diagnosis of PPLs. Methods: A systematic review of published literature evaluating the accuracy of r-EBUS-TBLB and CT-PTNB for the diagnosis of PPLs was performed to determine point sensitivity and specificity, and to construct a summary receiver-operating characteristic curve. Results: This review included 31 publications dealing with EBUS-TBLB and 14 publications dealing with CT-PTNB for the diagnosis of PPLs. EBUS-TBLB had point sensitivity of 0.69 (95% CI: 0.67–0.71) for the diagnosis of peripheral lung cancer (PLC), which was lower than the sensitivity of CT-PTNB (0.94, 95% CI: 0.94–0.95). However, the complication rates observed with EBUS-TBLB were lower than those reported for CT-PTNB. Conclusions: This meta-analysis showed that EBUS-TBLB is a safe and relatively accurate tool in the investigation of PLC. Although the yield remains lower than that of CT-PTNB, the procedural risks are lower. UR - https://tlcr.amegroups.org/article/view/11855