TY - JOUR AU - Carnio, Simona AU - Novello, Silvia AU - Papotti, Mauro AU - Loiacono, Marco AU - Scaglio, Giorgio Vittorio PY - 2013 TI - Prognostic and predictive biomarkers in early stage non-small cell lung cancer: tumor based approaches including gene signatures JF - Translational Lung Cancer Research; Vol 2, No 5 (October 22, 2013): Translational Lung Cancer Research (Management of early stage non-small cell lung cancer - Guest Editor: Heather Wakelee) Y2 - 2013 KW - N2 - In early stage non-small cell lung cancer (NSCLC) large randomized trials have demonstrated that in patients with radically resected disease adjuvant chemotherapy improves 5-year survival rates. However, a customization of systemic treatment is needed to avoid treatments in patients cured by surgery alone or to justify the use of adjuvant chemotherapy in high risk patients, including those in stage IA. Recently, the possibility of identifying prognostic and predictive factors related to the genetic signatures of the tumor that could affect adjuvant and neo-adjuvant treatment choices for resectable non-small cell lung cancer (NSCLC) has been of interest. This review summarizes the current status and future opportunities for clinical application of genotyping and genomic tests in early NSCLC. UR - https://tlcr.amegroups.org/article/view/1610