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Targeted therapy in NSCLC driven by HER2 insertions

  
@article{TLCR2263,
	author = {Solange Peters and Stefan Zimmermann},
	title = {Targeted therapy in NSCLC driven by HER2 insertions},
	journal = {Translational Lung Cancer Research},
	volume = {3},
	number = {2},
	year = {2014},
	keywords = {},
	abstract = {HER2 mutations, largely exon 20 in-frame insertions, have been described as an oncogenic driver alteration in 1% to 4% of NSCLC, exclusively in adenocarcinoma histology. The prognostic implication of these alterations is not known. Phase I and II trial data suggest that afatinib, neratinib and dacomitinib have some activity in this molecular subgroup. No comparative data, or any data regarding the activity of pertuzumab or trastuzumab-emtansine is available. HER2 deregulation either by protein overexpression or gene amplification, has little clinical relevance to date, as trials investigating trastuzumab activity merely suggest a benefit in the very small minority of patients whose tumor highly overexpresses HER2, a subpopulation that amounts to 2% to 6% of mostly adenocarcinomas.},
	issn = {2226-4477},	url = {http://tlcr.amegroups.com/article/view/2263}
}