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Clinical development and approval of second generation ALK inhibitors for ALK rearranged lung cancer

  
@article{TLCR3041,
	author = {Daniel B. Costa},
	title = {Clinical development and approval of second generation ALK inhibitors for  ALK  rearranged lung cancer},
	journal = {Translational Lung Cancer Research},
	volume = {3},
	number = {6},
	year = {2014},
	keywords = {},
	abstract = {Lung cancers are heterogeneous tumors often characterized by mutations in oncogenes and tumor suppressor genes. Anaplastic lymphoma kinase (ALK) genomic aberrations were first identified in non-small cell lung cancer (NSCLC) in 2007 (1). We now know that a substantial fraction (approximately 5%) of all NSCLCs harbor rearrangements between ALK and fusion partners (such as EML4, TFG, KIF5B, KLC1 among others).},
	issn = {2226-4477},	url = {http://tlcr.amegroups.com/article/view/3041}
}