TY - JOUR AU - Deng, Qiuhua AU - Qiu, Yuan AU - Jia, Junmei AU - Tang, Hailing AU - Liu, Liping AU - Huang, Liyan AU - He, Dongyun AU - Dong, Xiaomeng AU - Yang, Haihong PY - 2019 TI - Genetic alteration profile of EGFR -mutant resected IIB–IIIA stage NSCLC and correlation to clinical outcomes JF - Translational Lung Cancer Research; Vol 8, No 6 (December 31, 2019): Translational Lung Cancer Research Y2 - 2019 KW - N2 - Background: Genetic alteration profile of epidermal growth factor receptor ( EGFR ) mutant resected non- small cell lung cancer (NSCLC) and its relationship with clinical outcomes remains to be illustrated and genetic biomarkers that can predict recurrence need to be figured out. Methods: Clinicopathological and follow-up information were collected for 99 EGFR -mutant resected NSCLC. Tumor sections were collected for genetic alteration detection. Targeted next-generation sequencing (NGS) was performed to detect somatic mutations within each sample using a 285-gene panel on the Ion Torrent platform. Results: Concurrent driver gene mutations were detected in 86 participants. Adjuvant therapy was a positive factor in disease-free survival (DFS) period, and patients receiving tyrosine kinase inhibitors (TKIs) gained the longest DFS. A total of 34 concurrent mutant driver genes were found. The median number of mutated driver genes for each sample was 2 (range, 0–12). TP53 and NOTCH1 were the most frequent concurrent mutant driver genes with rates of 53.54% and 25.25% respectively. The number of concurrent mutant genes did not have a significant effect on recurrence. Multivariable analysis found that mutations of ATM (P=0.021), KIT (P=0.002), FGFR2 (P MET (P=0.015), PDGFRA (P=0.042), RB1 (P=0.006), and wildtype NOTCH1 (P=0.032), ERBB4 (P=0.012), FGFR3 (P=0.035) were independent risk factors for the recurrence of resected EGFR mutant NSCLC. Conclusions: TP53 and NOTCH1 was the most common concurrent mutant driver gene. Mutations of ATM, KIT, FGFR2, MET, PDGFRA, RB1 , and wildtype NOTCH1, ERBB4, FGFR3 were independent risk factors for the recurrence of resected EGFR mutant NSCLC. UR - https://tlcr.amegroups.org/article/view/33708