@article{TLCR33897,
author = {Daniel A. Kobrinski and Haining Yang and Muaiad Kittaneh},
title = {BAP1: role in carcinogenesis and clinical implications},
journal = {Translational Lung Cancer Research},
volume = {9},
number = {Suppl 1},
year = {2019},
keywords = {},
abstract = {BRCA-1 associated protein 1 (BAP1) is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies and is gaining more recognition as a crucial gene that could be amenable to therapeutic manipulation. There is a growing interest in prevention and establishing cancer screening guidelines in patients with germline BAP1 mutations to aid with early detection and treatment of associated malignancies. We aim to give a concise review of BAP1 and its role in carcinogenesis, the BAP1 cancer predisposition syndrome and discuss clinical implications including suggested screening guidelines, and potential targeted therapeutic options.},
issn = {2226-4477}, url = {https://tlcr.amegroups.org/article/view/33897}
}