%0 Journal Article %T BAP1: role in carcinogenesis and clinical implications %A Kobrinski, Daniel A. %A Yang, Haining %A Kittaneh, Muaiad %J Translational Lung Cancer Research %D 2019 %B 2019 %9 %! BAP1: role in carcinogenesis and clinical implications %K %X BRCA-1 associated protein 1 ( BAP1 ) is a tumor suppressor gene that has been implicated in the pathogenesis of several malignancies and is gaining more recognition as a crucial gene that could be amenable to therapeutic manipulation. There is a growing interest in prevention and establishing cancer screening guidelines in patients with germline BAP1 mutations to aid with early detection and treatment of associated malignancies. We aim to give a concise review of BAP1 and its role in carcinogenesis, the BAP1 cancer predisposition syndrome and discuss clinical implications including suggested screening guidelines, and potential targeted therapeutic options. %U https://tlcr.amegroups.org/article/view/33897 %P S60-S66 %@ 2226-4477