TY - JOUR AU - Chen, Fangfang AU - Yao, Yanwen AU - Ma, Chunyan AU - Ma, Xingqun AU - Wang, Zhaofeng AU - Lv, Tangfeng AU - Xiao, Xinwu AU - Yin, Jie AU - Song, Yong PY - 2014 TI - Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer JF - Translational Lung Cancer Research; Vol 4, No 1 (February 24, 2015): Translational Lung Cancer Research Y2 - 2014 KW - N2 - Purpose: Ratio of maximum standardized uptake value to primary tumor size (SUV max /tumor size) was previously demonstrated to be a more important indicator of prognosis than primary tumor SUV max alone in surgically resected non-small cell lung cancer (NSCLC). The aim of this study was to investigate whether SUV max /tumor size was associated with response to first-line therapy and prognosis in patients with advanced NSCLC. Patients and methods: A retrospective review of patients who had a pretreatment 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) before receiving first-line therapy for advanced (III & IV) NSCLC was performed. Survival curves were stratified by median SUV max and SUV max / tumor size by the Kaplan-Meier method and statistical differences were assessed using the log-rank test. Multivariate proportional hazards (Cox) regression analyses were applied to test the SUV max ’s and SUV max / tumor size’s independency of other prognostic factors for the prediction of survival. Results: In total 181 patients were enrolled into the current study. Median overall survival (OS) was 15.4 months (range, 3.1-64.0 months), progression-free survival (PFS) was 5.6 months (range, 0.8-29.1 months), and post-progression survival (PPS) was 8.2 months (range, 0-51.3 months). The statistical analysis data indicated that only clinical response to first-line therapy (P=0.000, OR =6.555) was independent prognostic factors for PFS, stage (P=0.028, OR =1.673) was associated with PPS independently, and for OS, SUV max /tumor size (P=0.050, OR =1.656) and clinical response (P=0.002, OR =2.803) were all independent prognostic factors. Conclusions: SUV max /tumor size may be an important indicator of prognosis in patients with advanced NSCLC. UR - https://tlcr.amegroups.org/article/view/3440