TY - JOUR AU - O’Kane, Grainne M. AU - Leighl, Natasha B. PY - 2016 TI - Are immune checkpoint blockade monoclonal antibodies active against CNS metastases from NSCLC?—current evidence and future perspectives JF - Translational Lung Cancer Research; Vol 5, No 6 (December 29, 2016): Translational Lung Cancer Research (Emerging Treatment Options for Brain Metastases from Non-small Cell Lung Cancer) Y2 - 2016 KW - N2 - Brain metastases occur in approximately half of patients with non-small cell lung cancer (NSCLC) and are associated with a poor prognosis and an inferior quality of life. Historically systemic therapy has had a limited role in CNS disease with a reliance placed on local treatments. The emergence of targeted therapies and immune checkpoint inhibitors (ICIs) in recent years has dramatically changed the treatment landscape of NSCLC. Programmed cell death-1 (PD-1) inhibitors have demonstrated efficacy in three randomized trials and now represent standard second line therapy after platinum failure. Trials have largely excluded patients with symptomatic or untreated CNS disease as the brain has been considered an ‘immune-privileged’ organ. We review the evidence and future prospects of ICIs in treating brain metastases in NSCLC. UR - https://tlcr.amegroups.org/article/view/9971