David MacPherson, PhD

Fred Hutchinson Cancer Research Center, Division of Human Biology, Seattle, WA, USA

Dr. MacPherson did his graduate work with Tyler Jacks at MIT where his research focused on mouse models of retinoblastoma and other cancers. After graduating in 2005, he joined the faculty of the Carnegie Institution Department of Embryology as a Staff Associate, an alternative to traditional postdoctoral work, where he expanded his research program to include study of small cell lung cancer (SCLC). In 2012 he moved to the Fred Hutchinson Cancer Research Center as an Assistant Member, where he now leads a research group with a major focus on understanding the mutated genes that drive SCLC.  His research includes the generation and study of a panel of genetically engineered mouse models of SCLC harboring different driver gene mutations, as well as patient-derived xenograft models. His lab is using these tools to link mutations in specific genes to sensitivity towards novel therapeutic approaches.