Lung cancer screening: who pays? Who receives? The European perspectives
Review Article on Lung Cancer Screening

Lung cancer screening: who pays? Who receives? The European perspectives

Pierluigi Novellis1, Silvia Raimondi Cominesi1, Francesca Rossetti1, Michele Mondoni2, Vanesa Gregorc3, Giulia Veronesi1,4

1Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy; 2Department of Health Sciences, University of Milan, Respiratory Unit, ASST Santi Paolo e Carlo, Milan, Italy; 3Department of Medical Oncology, IRCCS San Raffaele Scientific Institute, Milan, Italy; 4Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy

Contributions: (I) Conception and design: G Veronesi; (II) Administrative Support: None; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: P Novellis, SR Cominesi, F Rossetti, G Veronesi; (V) Data analysis and interpretation: None; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Pierluigi Novellis. Division of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy. Email:;

Abstract: Lung cancer is the leading cause of cancer-related death worldwide, and its early detection is critical to achieving a curative treatment and to reducing mortality. Low-dose computed tomography (LDCT) is a highly sensitive technique for detecting noninvasive small lung tumors in high-risk populations. We here analyze the current status of lung cancer screening (LCS) from a European point of view. With economic burden of health care in most European countries resting on the state, it is important to reduce costs of screening and improve its effectiveness. Current cost-effectiveness analyses on LCS have indicated a favorable economic profile. The most recently published analysis reported an incremental cost-effectiveness ratio (ICER) of €3,297 per 1 life-year gained adjusted for the quality of life (QALY) and €2,944 per life-year gained, demonstrating a 90% probability of ICER being below €15,000 and a 98.1% probability of being below €25,000. Different risk models have been used to identify the target population; among these, the PLCOM2012 in particular allows for the selection of the population to be screened with high sensitivity. Risk models should also be employed to define screening intervals, which can reduce the general number of LDCT scans after the baseline round. Future perspectives of screening in a European scenario are related to the will of the policy makers to implement policy on a large scale and to improve the effectiveness of a broad screening of smoking-related disease, including cardiovascular prevention, by measuring coronary calcium score on LDCT. The employment of artificial intelligence (AI) in imaging interpretation, the use of liquid biopsies for the characterization of CT-detected undetermined nodules, and less invasive, personalized surgical treatments, will improve the effectiveness of LCS.

Keywords: Lung cancer screening (LCS); low-dose computed tomography (LDCT); risk models; European LCS

Submitted May 22, 2020. Accepted for publication Apr 12, 2021.

doi: 10.21037/tlcr-20-677


Lung cancer, which is the leading cause of cancer-related death worldwide, is responsible for 270,000 deaths yearly in Europe (1). Although the lung cancer mortality rate in men is projected to decline, in women it is predicted to rise, mainly due to the dissimilarity of gender-related smoking habits across generations, thus confirming the impact that cigarette smoking has on lung cancer in both sexes (2). Therefore, the first crucial step in lung cancer prevention should be smoking interruption, a point that is discussed with every single patient enrolled in lung cancer screening (LCS) protocols.

Most lung cancer patients are diagnosed in an advanced stage, with an overall 5-year survival of 18% (3). As the prognosis of lung cancer depends on tumor size and stage at diagnosis, early detection is critical to achieving a curative treatment and to reducing mortality.

It is well established that low-dose computed tomography (LDCT) is a highly sensitive technique for detecting noninvasive early lung tumors in the screening of high-risk populations (LCS) (4-13). Published in 2011, the large-sample, randomized National Lung Screening Trial (NLST) in the United States demonstrated that LDCT performed in high-risk patients reduces lung cancer mortality by more than 20% compared with groups screened by chest X-ray (13).

In Europe, several randomized screening trials comparing LDCT scan versus chest X-ray were released but had insufficient statistical power to demonstrate any mortality benefit (14). Recently, however, a large-sample European randomized controlled trial, the Dutch-Belgian Randomized Lung Cancer Screening Trial (NELSON study) reported that the 10-year lung cancer mortality in the LDCT screening group was 2.5 deaths per 1,000 person-years, while that in the control group was 3.30. The screening arm therefore showed a 24% lung cancer mortality reduction (cumulative incidence ratio for death from lung cancer of 0.76; P=0.01). It should be noted that in the screening arm, about 77.6% of diagnosed cancers were early stage (IA to II), while 71.6% of patients in the control arm were stage III to IV at diagnosis, indicating that early-stage diagnosis leads to a reduction in mortality (15).

Other European single-arm studies have analyzed oncological outcomes. In Milan for instance, the Continuous Observation of Smoking Subjects (COSMOS), a single-center nonrandomized LDCT screening study, showed high sensitivity (90.3%) and specificity (99.4%) for the first 5 years of follow-up and confirmed that 78% of detected tumors were localized (N0 M0); a high proportion (87%) of cancers were radically treated, and long-term oncological results were satisfactory with an overall 5-year survival of 78% (16).

Potential drawbacks

Despite its widely recognized value, LDCT screening in Europe has to overcome several obstacles in its implementation, especially regarding its economic impact (which is discussed below), ionizing radiation exposure, overdiagnosis (defined as the detection of a lung cancer that would not lead to patient’s death because of a slow growth rate and competing age-related risks for death), and false positives.

According to the retrospective evaluation in the 10-year COSMOS study, cumulative radiation exposure and a lifetime risk of radiation-induced cancer can be acceptable if we consider the substantial mortality reduction associated with LCS; in fact, in a worst case scenario, only 1 radiation-induced cancer would be expected in every 108 lung cancers detected after 10 years of LDCT-LCS. Nevertheless, it would be possible to further reduce exposure by improving the diagnostic flowchart and excluding low-risk patients to minimize unnecessary radiologic examinations (17). Furthermore, new CT scanners with optimized acquisition protocols that can reduce the dose by up to 40% and new reconstruction algorithms that can reduce the radiation dose by up to 80% and obtain an equivalent image quality are now available (18-20).

Some authors consider LDCT screening of limited utility in changing the natural history of lung cancer due to overdiagnosis (21-23) of indolent early-stage cancers considered of uncertain clinical relevance (23). Together with the potentially high false-positive rate, overdiagnosis is one of the most criticized drawbacks of LDCT screening. A retrospective analysis on the COSMOS population suggests that changes in size on sequential LDCT screening can help in the discrimination of aggressive versus indolent tumors by measuring the volume-doubling time (VDT) to classify them as fast growing (<400 days), slow growing (400 to 599 days), or indolent (>600 days). VDT seems to be an acceptable indicator of cancer aggressiveness and its analysis shows that only fewer than 10% of resected screened lung cancers have a VDT higher than 600, thus minimizing the problem of overdiagnosis. As this 10% of indolent cancers may include some of the overdiagnosed cancers and nonsurgical treatments, such as stereotactic ablative radiotherapy (SABR) or minimally invasive (video-assisted/robot-assisted), limited resections should be considered to reduce overtreatment (24). In the ITALUNG trial, a randomized controlled trial carried out in Tuscany from 2004 comparing LDCT-LCS to standard care, the number of cancer cases diagnosed was similar in the two arms, showing no overdiagnosis after an adequate follow-up period (25).

As far as false positives are concerned, during the first 6 years (from 2004–2005 to 2010) of the COSMOS study, only 14% of benign lesions underwent surgical biopsy (24) due to the application of positron emission tomography-CT (PET-CT) for preoperative assessment of indeterminate screening-detected lung nodules and the repetition of LDCT after 1 month in case of suspected inflammatory lesions (26). Even if the nodules had typical benign characteristics, half of them were PET-positive and half of them had a VTD in the rate of malignancy, and thus surgery was performed; fine-needle aspiration biopsy (FNAB) was not routinely used in this screening protocol. This percentage is lower than that reported in the NLST, where 25% of suspicious cases underwent invasive procedures for benign nodules (27), and that in the NELSON study, where 27% and 21% of cases underwent surgery for benign disease at baseline and in subsequent rounds, respectively (12). By contrast, the Danish LCS Trial reported that only 10% of benign cases underwent surgery using a protocol that combined PET-CT with VDT (28). Improved diagnostic protocols, a prolonged period of follow-up, and a multidisciplinary approach are critical to reducing invasive procedures for benign nodules that often cause unnecessary morbidity and resource utilization. Screening is therefore an important tool for reducing deaths from lung cancer and can be considered effective and safe.

In this review we explore some aspects of the screening process, particularly those regarding the cost-effectiveness analysis (CEA) and the optimization of target population selection and recruitment.

CEA in the European and International setting

It is necessary to demonstrate that LDCT-LCS can be cost-effectively implemented. LCS costs were initially (from 2000 to 2007) a predominantly North American interest, and early studies were published in the USA and Canada (29,30-42). A CEA based on NLST data, which compared an LDCT screening arm with a standard care arm in over 53,000 individuals, estimated a cost of USD $81,000 per quality-adjusted life-year (QALY) gained (30-36). Thus, the US Preventive Services Task Force (USPSTF) recommended screening for high-risk individuals (aged 55 to 80 years, with at least 30 pack-years smoking history and fewer than 15 years of smoking abstinence immediately before screening) (43), with private and public institutions covering costs. In Canada, a group conducted a CEA comparing patients undergoing LDCT against nonscreened individuals: the high-risk screening cost was estimated to be CAD $20,724 (in 2015) per QALY gained (34,35).

Nevertheless, it is difficult to apply these results to the European framework, where costs and reimbursements are markedly different from those in North America. Only recently (from 2014 to 2019), CEAs have been published in Europe (44-49). Two studies published in Germany examined the incremental cost-effectiveness ratio (ICER): one reported €19,302 per life-year gained and €30,241 per QALY and the other reported €16,754–23,847 per life-year (45,46). In the UK, two studies found an ICER lower than £11,000 per QALY (44,47); a more recent study found an ICER between £20,000 and £30,000 per QALY, but under extreme assumptions (very small cost advantage in treating stage I and stage IV, no increase in average survival between the screening and nonscreening scenarios) (48). Meanwhile, a Polish study reported an ICER of €1,353 per life-year gained (49).

For Italy, our group found an ICER of €3,297 per QALY gained and €2,944 per life-year gained (50). This is the most recent study covering this issue and included the new treatment options of advanced stage lung cancer. This model is based on a decision tree presenting the main contributors to costs, with each branch representing a divergence in the management of the screened patient; usual care arms and the alternatives were assigned probabilities of occurrence. Real-world cost data were estimated by summing all reimbursements paid to the hospital for hospitalizations, outpatient appointments, examinations, and medications, sorted by year of diagnosis and disease stage. The screening arm was composed of individuals enrolled in the COSMOS study (51) who represented a high-risk population, adapted by considering only those who met the more stringent eligibility criteria of the USPSTF. Patients diagnosed and treated for lung cancer in the Lombardy region of Italy constituted the nonscreening arm. Data on a sample of subjects surveyed in 2015 (52) were extrapolated to estimate individuals at high risk of lung cancer in Italy in 2017: the Italian National Institute of Statistics (ISTAT) (53) estimated a population of 17,757,163 people aged 55–80 years old in 2017, including 2,166,374 individuals at high risk of lung cancer. Based on the obtained ICERs, screening this population for 5 years would require an investment by the Italian Health Service of around €600 million at €120 million/year, which represents 2.4% of the yearly Italian budget for disease prevention (€5 billion). Further investigation of sensitivity using Monte Carlo simulations demonstrated a 55% probability of the ICER per life-year being less than €5,000, an 80% probability of being less than €10,000, a 90% probability of being less than €15,000, and a 98.1% probability of being less than the threshold of €25,000, as indicated by the UK’s the National Institute for Health and Care Excellence (NICE) introduction for new medical technologies (54). These low ICERs imply that screening can be implemented throughout Italy at relatively low cost, thereby cost-effectively saving the lives of many lung cancer patients.

The recent introduction of new targeted therapies with monoclonal antibodies and immunotherapy in the treatment of late-stage lung cancer has changed the natural history of mutation-bearing diseases. Despite their undeniable efficacy, these treatments are extremely expensive: osimertinib treatment, for example, could be more effective than chemotherapy in advanced lung cancer patients with an acquired epidermal growth factor receptor (EGFR) T790M mutation; nevertheless, this benefit has been associated with a significant cost increase, with average ICERs greater than US $200,000 per QALY in the United States and greater than US $30,000 per QALY in China. Considering the threshold of US $100,000 and US $23,815 per QALY gained in the USA and in China, respectively, osimertinib was not considered a cost-effective therapeutic strategy (55); now, however, owing to its associated survival advantage, osimertinib has been indicated as first-line therapy in the treatment of non-small cell lung cancer (NSCLC) since 2018. The capability of LCS to identify lung cancer in the early stages may decrease the total burden of overall lung cancer treatment by reducing the number of patients diagnosed at a late stage and thus those requiring molecular profile identification and expensive targeted therapies.

Selection of target population and screening interval: risk models

European healthcare systems are mainly nationalized, with charges being covered by governments. Costs are probably one of the factors that have limited the introduction of LCS into clinical practice. The use of different risk models can have a dual purpose: for one, it allows for the identification of subjects at higher risk of developing lung cancer; for another, it can create a tailored screening interval profile useful for designing a more personalized and cost-effective screening schedule. The NLST recruitment of subjects was based on pack-years ≥30, quit-time in former smokers of ≤15 years, and age 55 to 74 years. The USPSTF and the Centers for Medicare and Medicaid Services (CMS) recommendations applied the same criteria as the NLST, but used the ages of 55–80 and 55–77 years, respectively (43,56). The risk model associated with NLST has the power to identify 1 tumor out of 320 screened subjects (57). These values are difficult to apply in a European scenario.

LCS recruitment is based on smoking status and age. Assuming that age and cigarette smoking are the most important but not the sole risk factors for lung cancer development and considering the need for a more powerful system to select people at high risk of lung cancer, several risk models have been proposed over the years (51,58-76). However, many of them have been considered unsuitable, as they were validated in restricted or non-European populations or have only modest predictive power (59,60,62-68,70,71,73-76).

The Prostate, Lung, Colorectal, and Ovarian (PLCOm2012) Cancer Screening Trial (69) was thus remade in 2012 to estimate cancer development risk over 6 years. The model was built on a cohort of 80,375 individuals and with an external validation of 37,332 subjects. The PLCOm2012 prediction rules were evaluated at a 1.34% risk threshold. The PLCOm2012 model was demonstrated to be more successful than the NLST criteria: “sensitivities were 83.0% versus 71.1% (P<0.001), the specificities were 62.7% versus 62.9% (P=0.54), and the positive predictive values were 4.0% versus 3.4% (P=0.01)” (72). The model in fact identified 81 more cancers more than the NLST did.

Similarly, the Liverpool Lung Project (LLP) model was used to calculate the 5-year lung cancer risk in a population aged 40 to 80 years. The model was designed using 1,736 case-control-matched individuals in a population from Liverpool, UK. The LLP model was used in the United Kingdom Lung Screening trial. The trial used LDCT for the early detection of lung cancer in high-risk subjects (>5% risk over 5 years, according to the LLP model) aged 50 to 75 years (77). The high-risk threshold may be a cost-effective method, as it excludes a high proportion of controls, but it will, however, only capture a small proportion of cases. The United Kingdom Lung Screening uses a single screen rather than multiple screens of the identified individuals. This is done to maximize the yield of the screening test, making it more cost-effective (78). Recently, the NHS England Lung Health Projects (79) has been using both the PLCOM2012 and the LLP v.2 model, with the thresholds adopted for screening the eligibility of PLCOM2012 being ≥1.3%, ≥1.5%, and ≥2.0%.

In order to improve screening and limit its costs, in 2011, we developed a risk model to optimize the interval between the screening rounds according to individual risk. We stratified the population of the COSMOS study integrating characteristics of the subjects (i.e., age, gender, smoking habit) with findings of baseline CT scans (emphysema and features of nodules) (51). Presence of nonsolid nodules [risk ratio (RR): 10.1, 95% confidence interval (CI): 5.57–18.5], nodule size more than 8 mm (RR: 9.89, 95% CI: 5.84–16.8), and emphysema (RR: 2.36, 95% CI: 1.59–3.49) at baseline CT were all significant predictors of malignity.

The PLCOm2012 risk model associated with the Maisonneuve model that integrates CT findings at baseline screening could help in both the selection of target population and the definition of the optimal interval of screening. The Italian SMAC study represents an external validation of this model. Other studies have been aimed in this direction: in 2019, Pastorino et al. presented the results of a risk model to the World Conference on Lung Cancer (80); they reported that baseline blood microRNA associated with LDCT could predict lung cancer risk and mortality at 4 years and that lung cancer risk was significantly higher in subjects with a single-positive [hazard ratio (HR): 6] and double-positive test (HR: 36.6). According to this model, blood microRNA plus LDCT would allow optimal screening intensity and reduce unnecessary repetition of LDCT, thus improving the efficacy of screening (80) (Figure 1).

Figure 1 In this schematic model, the current SMAC screening strategy is reapplied. We identify subjects to be screened using the PLCOm2012 risk model to select the population at high risk of developing lung cancer. After the first CT scan, a second risk (Maisonneuve model) model is used to determine the correct interval to perform the second round of CT in order to improve the effectiveness of the screening.

Future perspectives

Many aspects of LCS have been overlooked over the years to improve its cost-effectiveness. The future perspectives of LCS in Europe will involve several aspects. First, as LCS addresses the smoking population, LCS may be applied to the screening of other smoking-related diseases, including both cardiovascular and pulmonary disorders [e.g., emphysema/chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF)] (81,82). Notably, an early diagnosis of IPF might induce an early prescription of antifibrotic therapy with beneficial effects on survival (83).

Secondly, as LCS allows for the detection of more tumors at early stages, there should be a subsequent increase in the number of minimally invasive parenchyma-sparing surgical procedures. Other objectives could be the improvement of the CT reading process using artificial intelligence (AI) software and the search for biomarkers to facilitate speedier diagnoses without the need of invasive procedures.

Prevention and detection of cardiovascular diseases (CVD)

CVD were reported to be responsible for the majority of total deaths in LDCT study arms (13). Coronary artery calcification (CAC), extracoronary cardiac calcifications, and aortic aneurysm can all be detected on LDCT scans.

LCS gives offers the attractive opportunity to reduce CVD mortality through the concomitant assessment of CVD risk via coronary artery calcium quantification, a recognized marker of atherosclerosis (84).

CAC alone, however, is not sufficient for evaluating CVD risk (85). A recent consensus paper reported that CAC on a basal CT associated to the Framingham score can refine risk stratification (86). The NICE guidelines recommend the use of statin (atorvastatin 20 mg) in the case of poor control of cholesterol values associated with CAC expression (QRISK 2 ≥10%) (87). The QRISK 2 is an algorithm developed by the UK National Health Service that calculates the risk of heart attack or stroke over the ensuing 10 years (87).

In 2019, Ruparel et al.’s study demonstrated the following phenomena: (I) in a cohort of individuals undergoing an LDCT for LCS, 62% of participants had coronary calcium; (II) an increased QRISK 2 was associated with s higher value of CAC on LDCT; and (III) 98% of LCS-eligible individuals met the ≥10% 10-year CVD risk threshold required for statin primary prevention of CVD events in the UK (88). LDCT could therefore not only serve an important role in secondary prevention for lung cancer but also aid in the primary prevention of CVD.

Increase in minimally invasive surgical procedures

The main goal of LCS is to reduce mortality. However, to increase the effectiveness of LCS, other treatments should to be adapted and improved upon. Specifically, because of the increasing number of small, early-stage tumors detected by LCS, there should be a concurrent increase in the number of minimally invasive procedures that are associated with better and shorter postoperative hospitalizations and reduced costs.

Surgical results of the NLST indicated that 80% of patients received lobectomy, 4.1% pneumonectomy, and 16.1% sublobar resection (69% wedge resection), while only 29.6% (n=305) of the cohort had a thoracoscopic resection (89).

In the Danish LCS trial, 84% of surgical procedures on screen-detected cancers were performed by video-assisted thoracic surgery (90). This high number of minimally invasive procedures was not reported in other screening programs (91,92). Similarly, in the SMAC study, we treated the majority of cancers using a minimally invasive approach, specifically, a robot-assisted technique.

Abundant evidence supports the superiority of minimally invasive surgery of thoracotomy in terms of perioperative and oncological outcomes and postoperative quality of life and pain control (93-96). However, few data have been reported for anatomic sublobar resections for tumors diagnosed by screening. In the NLST, only 5% of resections were anatomic segmentectomies (89), while in the Danish LCS trial, this figure was only 2% (90) (Figure 2). Nevertheless, the number of anatomic segmentectomies is expected to increase in the future.

Figure 2 Lung cancer stage distribution in different randomized LDCT screening [NLST in (A), Nelson in (B)], and nonrandomized studies [COSMOS in (C)].

In recent years, robotic surgery has shown benefits in reducing mortality, shortening length of stay, and decreasing the severity of hospitalization (97). Moreover, it has been associated with a lower conversion-to-open rate and a lower 30-day complication rate (98). Robotic surgery has also demonstrated advantages in the field of segmentectomy (99-103). Robotic segmentectomies seem to be characterized by absence of major bleeding, an “oncologically acceptable” number of lymph nodes removed, 0% mortalities, and only 3.4% 30-month local recurrence (100). Robotic segmentectomies also show precise identification of the intersegmental plane in 100% of cases, thus facilitating radical resection (104). Minimally invasive sublobar resections could be the standard for slow-growing and small tumors detected at screening.

AI for radiological analysis

If screening is covered by the NHS, the number of LDCT scans will greatly increase. Guidelines today help in therapeutic decision-making when a solitary lung nodule is detected (105,106); however, the radiological reporting of the exams requires a significant amount of medical expertise and labor. New software based on AI can aid in analyzing nodule size, margins, attenuation, and other radiological features without the subjective judgement of the radiologist. In the UK, the IDEAL study (Artificial Intelligence and Big Data for Early Lung Cancer Diagnosis), developed by Optellum Ltd., used AI to evaluate the probability of a lung nodule to be malignant. As a risk prediction model, the lung cancer prediction convolutional neural network (LCP-CNN) was constructed using a machine learning algorithm (107). Recently Baldwin (108) and colleagues compared the performance of the LCP-CNN with the Brock University model recommended in UK guidelines. Their results showed an area under curve of 89.6% for LCP-CNN (95% CI: 87.6–91.5), compared with 86.8% (95% CI: 84.3–89.1) of the Brock model (P≤0.005). The LCP-CNN score provided better discrimination, with a larger proportion of benign nodules identified without missing cancers, thus reducing the proportion of follow-up CT scans and saving resources. As AI technology progresses, CT reports will serve as their own validation, making the CT screening faster and more cost-effective.

Liquid biopsies for preoperative diagnosis

The potential risk related to the rising number of lung nodules detected by LDCT may translate into an increase in invasive diagnostic procedures and diagnostic surgery. Liquid biopsy may be the solution to this issue. Circulating exosomes (109), microRNA (110), cell-free DNA (cfDNA), and circulating tumor cells (CTCs) are being evaluated for their clinical utility (111). Thus far, research into cfDNAs and CTCs has yielded the most promising results. cfDNA is the portion of circulating DNA in bloodstream that is passively released from apoptotic and necrotic cells or indirectly by tumor-associated macrophages. Migration of CTCs in the bloodstream is an early event in carcinogenesis: they are released by cancer tissue as single cells or clusters of cells that can be isolated in the peripheral blood in different ways (111). Ilie et al. examined the presence of “sentinel” CTCs in COPD patients without radiologically detectable lung cancer and screened them annually with LDCT: CTCs were detected in 3% of COPD patients, and, in 1 to 4 years, these patients developed a radiologically detectable lung nodule, leading to prompt surgical intervention of an early-stage tumor (112).

These results support the use of liquid biopsies as a tool for noninvasive preoperative diagnosis of lung cancers in the LCS setting, which can reduce the number of invasive diagnostic procedures, such as endobronchial ultrasound-guided transbronchial needle aspiration, CT-guided biopsies and diagnostic surgeries, and improve the effectiveness of the treatment by reducing the time required for these preoperative invasive diagnostic procedures.


It is well established that the application of LCS can reduce mortality, justifying its adoption by European public healthcare systems. This, however, strictly necessitates that LCS be rendered as cost-effective as possible. To improve effectiveness, risk models should be used according to the individual risk of the subjects both for the selection of the screening population and for the identification of optimal screening round intervals. This would provide suitable subjects for screening and individually tailored screening intervals.

CVD are the major cause of morbidity and mortality in populations eligible for screening: as the risk factors between lung cancer and CVD overlap, LCS could play an important role in prevention of smoking-related pathologies.

Finally, the use of AI in the interpretation of CT images and liquid biopsies for the histological and molecular definition of neoplasms could further improve the effectiveness of screening.


Funding: None.


Provenance and Peer Review: This article was commissioned by the guest editors (Paul Van Schil and Annemiek Snoeckx) for the series “Lung cancer screening” published in Translational Lung Cancer Research. The article has undergone external peer review.

Peer Review File: Available at

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at The series “Lung cancer screening” was commissioned by the editorial office without any funding or sponsorship. PN reports grants from Umberto Veronesi Foundation (FUV). GV reports grants from Associazione Italiana per la Ricerca sul Cancro (AIRC), Ministry of Health, Istituto Nazionale Assicurazione Infortuni sul Lavoro; outside the submitted work, she has received honoraria from Ab Medica SpA. The authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Cite this article as: Novellis P, Cominesi SR, Rossetti F, Mondoni M, Gregorc V, Veronesi G. Lung cancer screening: who pays? Who receives? The European perspectives. Transl Lung Cancer Res 2021;10(5):2395-2406. doi: 10.21037/tlcr-20-677