Vol 10, No 2 (February 2021): Translational Lung Cancer Research

Original Article

A nomogram prognostic model for large cell lung cancer: analysis from the Surveillance, Epidemiology and End Results Database
Gang Lin, Kang Qi, Bing Liu, Haibo Liu, Jian Li
Comprehensive genomic profiling of combined small cell lung cancer
Jing Zhang, Liping Zhang, Jie Luo, Tao Ge, Pengyu Fan, Liangdong Sun, Likun Hou, Junqiang Li, Huansha Yu, Chunxiao Wu, Yuming Zhu, Chunyan Wu, Gening Jiang, Giancarlo Troncone, Jyoti Malhotra, Katsuhiro Okuda, Mariacarmela Santarpia, Rita Zamarchi, Taichiro Goto, Andrés F. Cardona, Jianfang Xu, Qiankun Chen, Zhonghong Zhang, Peng Zhang, written on behalf of the AME Lung Cancer Collaborative Group
Hyponatremia as a prognostic factor in non-small cell lung cancer: a systematic review and meta-analysis
Birgitte Sandfeld-Paulsen, Ninna Aggerholm-Pedersen, Anne Winther-Larsen
EGFR variant allele frequency predicts EGFR-TKI efficacy in lung adenocarcinoma: a multicenter study
Balazs Gieszer, Zsolt Megyesfalvi, Viktoria Dulai, Judit Papay, Ilona Kovalszky, Jozsef Timar, Janos Fillinger, Tunde Harko, Orsolya Pipek, Vanda Teglasi, Eszter Regos, Gergo Papp, Zoltan Szallasi, Viktoria Laszlo, Ferenc Renyi-Vamos, Gabriella Galffy, Csaba Bodor, Balazs Dome, Judit Moldvay
The effects of bisphosphonate and radiation therapy in bone-metastatic lung adenocarcinoma: the impact of KRAS mutation
Peter Radeczky, Zsolt Megyesfalvi, Viktoria Laszlo, Janos Fillinger, Judit Moldvay, Erzsebet Raso, Erzsebet Schlegl, Tamas Barbai, Jozsef Timar, Ferenc Renyi-Vamos, Balazs Dome, Balazs Hegedus
PD-1 restrains IL-17A production from γδ T cells to modulate acute radiation-induced lung injury
Yuling Sheng, Kun Chen, Wei Jiang, Zhiyuan Wu, Wenjue Zhang, Hao Jing, Luhua Wang, Chunfeng Qu, Hua Ren
Programmed death-ligand 1 expression level as a predictor of EGFR tyrosine kinase inhibitor efficacy in lung adenocarcinoma
Minsu Kang, Changhee Park, Se Hyun Kim, Sock Won Yoon, Koung Jin Suh, Yu Jung Kim, Chan-Young Ock, Miso Kim, Bhumsuk Keam, Tae Min Kim, Dong-Wan Kim, Dae Seog Heo, Jong Seok Lee
Randomized phase II trial of uracil/tegafur and cisplatin versus pemetrexed and cisplatin with concurrent thoracic radiotherapy for locally advanced unresectable stage III non-squamous non-small cell lung cancer: NJLCG1001
Kana Watanabe, Yukihiro Toi, Atsushi Nakamura, Ryosuke Chiba, Masachika Akiyama, Jun Sakakibara-Konishi, Hisashi Tanaka, Naruo Yoshimura, Eisaku Miyauchi, Taku Nakagawa, Ryotaro Igusa, Hiroyuki Minemura, Yoshiaki Mori, Keisuke Fujimoto, Haruo Matsushita, Fumiaki Takahashi, Tatsuro Fukuhara, Akira Inoue, Shunichi Sugawara, Makoto Maemondo, North Japan Lung Cancer Study Group, Sendai, Japan
Feasibility of implementing a national lung cancer screening program: Interim results from the Korean Lung Cancer Screening Project (K-LUCAS)
Jaeho Lee, Yeol Kim, Hyae Young Kim, Jin Mo Goo, Juntae Lim, Choon-Taek Lee, Seung Hun Jang, Won-Chul Lee, Chan Wha Lee, Kui Son Choi, Boyoung Park, Duk Hyoung Lee, for the K-LUCAS Trial Investigators
KRASG12C/TP53 co-mutations identify long-term responders to first line palliative treatment with pembrolizumab monotherapy in PD-L1 high (≥50%) lung adenocarcinoma
Nikolaj Frost, Jens Kollmeier, Claudia Vollbrecht, Christian Grah, Burkhard Matthes, Dennis Pultermann, Maximilian von Laffert, Heike Lüders, Elisabeth Olive, Matthias Raspe, Thomas Mairinger, Sebastian Ochsenreither, Torsten Blum, Michael Hummel, Norbert Suttorp, Martin Witzenrath, Christian Grohé
Exon 20 YVMA insertion is associated with high incidence of brain metastasis and inferior outcome of chemotherapy in advanced non-small cell lung cancer patients with HER2 kinase domain mutations
Shuo Yang, Yan Wang, Chao Zhao, Xuefei Li, Qian Liu, Shiqi Mao, Yiwei Liu, Xiaofei Yu, Wanying Wang, Qinrun Tian, Yingying Pan, Anwen Xiong, Bin Chen, Guanghui Gao, Wei Li, Yayi He, Fengying Wu, Xiaoxia Chen, Chunxia Su, Shengxiang Ren, Caicun Zhou
Glypican-1 is a novel immunohistochemical marker to differentiate poorly differentiated squamous cell carcinoma from solid predominant adenocarcinoma of the lung
Yuichiro Kai, Vishwa Jeet Amatya, Kei Kushitani, Takahiro Kambara, Rui Suzuki, Yutaro Fujii, Yasuhiro Tsutani, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima
Novel risk scoring system for immune checkpoint inhibitors treatment in non-small cell lung cancer
Chuling Li, Meiqi Shi, Xinqing Lin, Yongchang Zhang, Shaorong Yu, Chengzhi Zhou, Nong Yang, Jianya Zhang, Fang Zhang, Tangfeng Lv, Hongbing Liu, Yong Song
Vimentin expression status is a potential biomarker for brain metastasis development in EGFR-mutant NSCLC patients
Rattanawadee Teocharoen, Komkrit Ruangritchankul, Chanida Vinayanuwattikun, Virote Sriuranpong, Piyada Sitthideatphaiboon
An immune-related gene expression signature predicts brain metastasis in lung adenocarcinoma patients after surgery: gene expression profile and immunohistochemical analyses
Young Wha Koh, Jae-Ho Han, Seokjin Haam, Hyun Woo Lee
A large real-world cohort study of examined lymph node standards for adequate nodal staging in early non-small cell lung cancer
Zhihua Zhu, Zhengbo Song, Wenjie Jiao, Weijian Mei, Chunwei Xu, Qinghua Huang, Chaolun An, Jianguang Shi, Wenxian Wang, Guiping Yu, Pingli Sun, Yinbin Zhang, Jianfei Shen, Yong Song, Jun Qian, Wang Yao, Han Yang, written on behalf of AME Lung Cancer Collaborative Group
Prognostic and predictive effect of KRAS gene copy number and mutation status in early stage non-small cell lung cancer patients
Andrea S. Fung, Maryam Karimi, Stefan Michiels, Lesley Seymour, Elisabeth Brambilla, Thierry Le-Chevalier, Jean-Charles Soria, Robert Kratzke, Stephen L. Graziano, Siddhartha Devarakonda, Ramaswamy Govindan, Ming-Sound Tsao, Frances A. Shepherd, on behalf of the LACE-Bio Collaborative Group
Fruquintinib with gefitinib as first-line therapy in patients carrying EGFR mutations with advanced non-small cell lung cancer: a single-arm, phase II study
Shun Lu, Jian-Ying Zhou, Xiao-Min Niu, Jian-Ya Zhou, Hong Jian, Hong-Yan Yin, Sha Guan, Lin-Fang Wang, Ke Li, James He, Wei-Guo Su
The prognostic impact of circulating homeobox A9 methylated DNA in advanced non-small cell lung cancer
Sara Witting Christensen Wen, Rikke Fredslund Andersen, Torben Frøstrup Hansen, Christa Haugaard Nyhus, Henrik Hager, Ole Hilberg, Anders Jakobsen
Preoperative peripheral blood neutrophil-to-lymphocyte ratios (NLR) and platelet-to-lymphocyte ratio (PLR) related nomograms predict the survival of patients with limited-stage small-cell lung cancer
Chunji Chen, Haitang Yang, Deng Cai, Lujie Xiang, Wentao Fang, Rui Wang
Comprehensive evaluation of the clinical utility of plasma EGFR test in non-small cell lung cancer patients with acquired resistance to first-line EGFR inhibitors
Hongsik Kim, Hyun Ae Jung, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
Apatinib with etoposide capsules as a third- or further-line therapy for extensive-stage small cell lung cancer: an open-label, multicenter, single-arm phase II trial
Zhen He, Hanqiong Zhou, Junsheng Wang, Ding Li, Xudong Zhang, Pengyuan Wang, Tianjiang Ma, Yueqiang Zhang, Chuntao Tian, Yunfang Chen, Minglei Zou, Yu Han, Cong Xu, Shuxiang Ma, Lili Wang, Xuan Wu, Gongbin Chen, Qiming Wang
Segmental resection is associated with decreased survival in patients with stage IA non-small cell lung cancer with a tumor size of 21–30 mm
Xiangyang Yu, Rusi Zhang, Mengqi Zhang, Yongbin Lin, Xuewen Zhang, Yingsheng Wen, Longjun Yang, Zirui Huang, Gongming Wang, Dechang Zhao, Michel Gonzalez, Jean-Marc Baste, Rene Horsleben Petersen, Calvin S. H. Ng, Alessandro Brunelli, Lie Zheng, Lanjun Zhang, written on behalf of the AME Thoracic Surgery Collaborative Group
Cell-free DNA from cerebrospinal fluid can be used to detect the EGFR mutation status of lung adenocarcinoma patients with central nervous system metastasis
Yang Liu, Sen Yang, Jiuzhou Zhao, Zhen He, Jie Ma, Yongjun Guo, Wei Wang, Akihiko Yoshizawa, Arsela Prelaj, Marcello Tiseo, Nicola Normanno, Paul E. Van Schil, Qiming Wang, Xiaopeng Yang
Delivery of gefitinib with an immunostimulatory nanocarrier improves therapeutic efficacy in lung cancer
Dingwei Diao, Jianxue Zhai, Jianjun Yang, Hua Wu, Jianjun Jiang, Xiaoying Dong, Antonio Passaro, Beatrice Aramini, Shuan Rao, Kaican Cai
TIPE3 promotes non-small cell lung cancer progression via the protein kinase B/extracellular signal-regulated kinase 1/2-glycogen synthase kinase 3β-β-catenin/Snail axis
Qiang Li, Dongmei Yu, Zhengyuan Yu, Qian Gao, Ruifang Chen, Lin Zhou, Rong Wang, Yan Li, Yulan Qian, Jun Zhao, Rafael Rosell, Min Tao, Yufeng Xie, Chun Xu
A machine learning-based prediction of the micropapillary/solid growth pattern in invasive lung adenocarcinoma with radiomics
Bingxi He, Yongxiang Song, Lili Wang, Tingting Wang, Yunlang She, Likun Hou, Lei Zhang, Chunyan Wu, Benson A. Babu, Ulas Bagci, Tayab Waseem, Minglei Yang, Dong Xie, Chang Chen
Identifying the prognostic significance of B3GNT3 with PD-L1 expression in lung adenocarcinoma
Xuefeng Leng, Shiyou Wei, Jiandong Mei, Senyi Deng, Zhenyu Yang, Zheng Liu, Chenglin Guo, Yulan Deng, Liang Xia, Jiahan Cheng, Kejia Zhao, Fanyi Gan, Chuan Li, Kenneth W. Merrell, Julian R. Molina, Giulio Metro, Lunxu Liu
Identification of serum biomarkers to predict pemetrexed/platinum chemotherapy efficacy for advanced lung adenocarcinoma patients by data-independent acquisition (DIA) mass spectrometry analysis with parallel reaction monitoring (PRM) verification
Bo Jia, Xinghui Zhao, Di Wu, Zhi Dong, Yujia Chi, Jun Zhao, Meina Wu, Tongtong An, Yuyan Wang, Minglei Zhuo, Jianjie Li, Xiaoling Chen, Guangming Tian, Jieran Long, Xue Yang, Hanxiao Chen, Jingjing Wang, Xiaoyu Zhai, Sheng Li, Junfeng Li, Menglei Ma, Yuling He, Lingdong Kong, Luka Brcic, Jian Fang, Ziping Wang
Circulating tumor cells can predict the prognosis of patients with non-small cell lung cancer after resection: a retrospective study
Zhao Li, Ke Xu, Alfredo Tartarone, Mariacarmela Santarpia, Yuming Zhu, Gening Jiang
Triptolide inhibits epithelial-mesenchymal transition phenotype through the p70S6k/GSK3/β-catenin signaling pathway in taxol-resistant human lung adenocarcinoma
Yu Tian, Peiwei Li, Zhaohua Xiao, Jie Zhou, Xia Xue, Ning Jiang, Chuanliang Peng, Licun Wu, Hui Tian, Helmut Popper, Mau-Ern Poh, Fabrizio Marcucci, Chengke Zhang, Xiaogang Zhao
Neoadjuvant programmed cell death protein 1 inhibitors combined with chemotherapy in resectable non-small cell lung cancer: an open-label, multicenter, single-arm study
Hongtao Duan, Tianhu Wang, Zhilin Luo, Liping Tong, Xiaoping Dong, Yong Zhang, Muhammad Zubair Afzal, Pierpaolo Correale, Honggang Liu, Tao Jiang, Xiaolong Yan

Case Report

Pembrolizumab-induced myocarditis in a patient with malignant mesothelioma: plasma exchange as a successful emerging therapy—case report
Sanziana R. I. Schiopu, Lukas Käsmann, Ulf Schönermarck, Michael Fischereder, Ulrich Grabmaier, Farkhad Manapov, Josefine Rauch, Martin Orban

Editorial on Implementation of CT-based Screening of Lung Cancer1

Editorial on implementation of CT-based screening of lung cancer
Witold Rzyman

Review Article on Implementation of CT-based Screening of Lung Cancer1

Implementation of lung cancer screening: what are the main issues?
Carlijn M. van der Aalst, Kevin ten Haaf, Harry J. de Koning, for the 4-IN-THE-LUNG-RUN Consortium
Implementation of low-dose CT screening in two different health care systems: Mount Sinai Healthcare System and Phoenix VA Health Care System
Claudia I. Henschke, David F. Yankelevitz, Artit Jirapatnakul, Rowena Yip, Vivian Reccoppa, Charlene Benjamin, Tserling Llamo, Angel Williams, Simon Liu, Daniel Max, Samuel M. Aguayo, Providencia Morales, Brian J. Igel, Hamed Abbaszadegan, Peter A. Fredricks, Daniel P. Garcia, Paska A. Permana, Janet Fawcett, Samir Sultan, Lorenza A. Murphy

Original Article on Implementation of CT-based Screening of Lung Cancer1

Performance of various risk prediction models in a large lung cancer screening cohort in Gdańsk, Poland—a comparative study
Marcin Ostrowski, Franciszek Bińczyk, Tomasz Marjański, Robert Dziedzic, Sylwia Pisiak, Sylwia Małgorzewicz, Mariusz Adamek, Joanna Polańska, Witold Rzyman

Review Article on Implementation of CT-based Screening of Lung Cancer1

Participation in lung cancer screening
David R. Baldwin, Kate Brain, Samantha Quaife
Lung cancer screening and smoking cessation efforts
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
A narrative review of invasive diagnostics and treatment of early lung cancer
Robert Dziedzic, Tomasz Marjański, Witold Rzyman
Pulmonary nodule radiological diagnostic algorithm in lung cancer screening
Katarzyna Dziadziuszko, Edyta Szurowska
Overdiagnosis in lung cancer screening
David F. Yankelevitz, Claudia I. Henschke
Added benefits of early detection of other diseases on low-dose CT screening
Rowena Yip, Artit Jirapatnakul, Minxia Hu, Xiangmeng Chen, Dan Han, Teng Ma, Yeqing Zhu, Mary M. Salvatore, Laurie R. Margolies, David F. Yankelevitz, Claudia I. Henschke, for the I-ELCAP Investigators
Latest CT technologies in lung cancer screening: protocols and radiation dose reduction
Marleen Vonder, Monique D. Dorrius, Rozemarijn Vliegenthart
Molecular biomarkers in early stage lung cancer
María Rodríguez, Daniel Ajona, Luis M. Seijo, Julián Sanz, Karmele Valencia, Jesús Corral, Miguel Mesa-Guzmán, Rubén Pío, Alfonso Calvo, María D. Lozano, Javier J. Zulueta, Luis M. Montuenga
Radiomics and artificial intelligence in lung cancer screening
Franciszek Binczyk, Wojciech Prazuch, Paweł Bozek, Joanna Polanska

Disclosure:

1. The series “Implementation of CT-based screening of lung cancer” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Witold Rzyman served as the unpaid Guest Editor for the series.