TY - JOUR AU - Hardavella, Georgia AU - George, Rachel AU - Sethi, Tariq PY - 2016 TI - Lung cancer stem cells—characteristics, phenotype JF - Translational Lung Cancer Research; Vol 5, No 3 (June 30, 2016): Translational Lung Cancer Research (The role of Nurses and Allied Health Professionals in lung cancer and mesothelioma care)<sup>1</sup> Y2 - 2016 KW - N2 - Lung cancer remains a major cause of cancer-related deaths worldwide with unfavourable prognosis mainly due to the late stage of disease at presentation. High incidence and disease recurrence rates are a fact despite advances in treatment. Ongoing experimental and clinical observations suggest that the malignant phenotype in lung cancer is sustained by lung cancer stem cells (CSCs) which are putative stem cells situated throughout the airways that have the potential of initiating lung cancer formation. These cells share the common characteristic of increased proliferation and differentiation, long life span and resistance to chemotherapy and radiation therapy. This review summarises the current knowledge on their characteristics and phenotype. UR - https://tlcr.amegroups.org/article/view/6956