Vol 7, No 6 (December 2018): Translational Lung Cancer Research (Current Knowledge and Future Perspectives on Tumor Mutational Burden in Non-small Cell Lung Cancer)

Original Article

A scalable solution for tumor mutational burden from formalinfixed, paraffin-embedded samples using the Oncomine Tumor Mutation Load Assay
Ruchi Chaudhary, Luca Quagliata, Jermann Philip Martin, Ilaria Alborelli, Dinesh Cyanam, Vinay Mittal, Warren Tom, Janice Au-Young, Seth Sadis, Fiona Hyland

Review Article

Tumor mutational burden assessment as a predictive biomarker for immunotherapy in lung cancer patients: getting ready for prime-time or not?
Simon Heeke, Paul Hofman
The clinical utility of tumor mutational burden in non-small cell lung cancer
Laurent Greillier, Pascale Tomasini, Fabrice Barlesi
Clinical utility of tumor mutational burden in patients with nonsmall cell lung cancer treated with immunotherapy
Lizza E. Hendriks, Etienne Rouleau, Benjamin Besse
Methods of measurement for tumor mutational burden in tumor tissue
Bárbara Meléndez, Claude Van Campenhout, Sandrine Rorive, Myriam Remmelink, Isabelle Salmon, Nicky D’Haene
Measuring tumor mutation burden in non-small cell lung cancer: tissue versus liquid biopsy
Francesca Fenizia, Raffaella Pasquale, Cristin Roma, Francesca Bergantino, Alessia Iannaccone, Nicola Normanno
Approach to evaluating tumor mutational burden in routine clinical practice
John Truesdell, Vincent A. Miller, David Fabrizio
Predictive markers for anti-PD-1/PD-L1 therapy in non-small cell lung cancer—where are we?
Matthew Evans, Brendan O’Sullivan, Matthew Smith, Philippe Taniere
Challenges and unanswered questions for the next decade of immune-oncology research in NSCLC
Niki Karachaliou, Manuel Fernandez-Bruno, Jillian Wilhelmina Paulina Bracht, Rafael Rosell
Implementing tumor mutational burden (TMB) analysis in routine diagnostics—a primer for molecular pathologists and clinicians
Michael Allgäuer, Jan Budczies, Petros Christopoulos, Volker Endris, Amelie Lier, Eugen Rempel, Anna-Lena Volckmar, Martina Kirchner, Moritz von Winterfeld, Jonas Leichsenring, Olaf Neumann, Stefan Fröhling, Roland Penzel, Michael Thomas, Peter Schirmacher, Albrecht Stenzinger


The focused issue “Current Knowledge and Future Perspectives on Tumor Mutational Burden in Non-small Cell Lung Cancer” was commissioned by the editorial office, Translational Lung Cancer Research without any sponsorship or funding. Marius Ilie and Paul Hofman served as the unpaid Guest Editors for the focused issue.