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Original Article

Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study
Alexander Mathilakathu, Sabrina Borchert, Michael Wessolly, Elena Mairinger, Hendrik Beckert, Julia Steinborn, Thomas Hager, Daniel C. Christoph, Jens Kollmeier, Jeremias Wohlschlaeger, Thomas Mairinger, Kurt Werner Schmid, Robert F. H. Walter, Luka Brcic, Fabian D. Mairinger
Diagnosis-to-surgery interval and survival for different histologies of stage I–IIA lung cancer
Lu Zhang, Mei-Chin Hsieh, Lior Rennert, Paige Neroda, Xiao-Cheng Wu, Chindo Hicks, Jiande Wu, Ronald Gimbel
Bevacizumab plus platinum-based chemotherapy in advanced non-squamous non-small-cell lung cancer: a randomized, open- label phase 2 study (CLEAR)
Hibiki Udagawa, Eri Sugiyama, Toshiyuki Harada, Shinji Atagi, Ryo Koyama, Satoshi Watanabe, Yukiko Nakamura, Daijiro Harada, Osamu Hataji, Fumihiro Tanaka, Hiroshi Kida, Miyako Satouchi, Ken Maeno, Akira Inoue, Kiyotaka Yoh, Yuki Yamane, Yoshiko Urata, Hiroshige Yoshioka, Takeharu Yamanaka, Koichi Goto
Tumor PD-L1 expression is associated with outcomes in stage III non-small cell lung cancer (NSCLC) patients treated with consolidation durvalumab
Khalid Jazieh, Mohamed Gad, Anas Saad, Wei Wei, Nathan A. Pennell
Randomized phase II trial of a first-in-human cancer cell lysate vaccine in patients with thoracic malignancies
Mary Zhang, Julie A. Hong, Tricia F. Kunst, Colleen D. Bond, Cara M. Kenney, Cheryl L. Warga, Javier Yeray, Min-Jung Lee, Akira Yuno, Sunmin Lee, Markku Miettinen, R. Taylor Ripley, Chuong D. Hoang, Sacha Gnjatic, Jane B. Trepel, David S. Schrump
Efficacy of docetaxel plus ramucirumab as palliative second-line therapy following first-line chemotherapy plus immune-checkpoint-inhibitor combination treatment in patients with non-small cell lung cancer (NSCLC) UICC stage IV
Wolfgang M. Brueckl, Martin Reck, Achim Rittmeyer, Jens Kollmeier, Claas Wesseler, Gunther H. Wiest, Petros Christopoulos, Albrecht Stenzinger, Amanda Tufman, Petra Hoffknecht, Bernhard Ulm, Fabian Reich, Joachim H. Ficker, Eckart Laack
Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—a trial-level meta-analysis in PD-L1 selected subgroups
Francesco Passiglia, Antonio Galvano, Valerio Gristina, Nadia Barraco, Marta Castiglia, Alessandro Perez, Maria La Mantia, Antonio Russo, Viviana Bazan
Shared decision-making for prophylactic cranial irradiation in extensive-stage small-cell lung cancer: an exploratory study
Anshu Ankolekar, Dirk De Ruysscher, Bart Reymen, Ruud Houben, Andre Dekker, Cheryl Roumen, Rianne Fijten
Subsequent systemic therapy for non-small cell lung cancer patients with immune checkpoint inhibitor-related interstitial lung disease
Yusuke Sato, Satoshi Watanabe, Takeshi Ota, Kohei Kushiro, Toshiya Fujisaki, Miho Takahashi, Aya Ohtsubo, Satoshi Shoji, Koichiro Nozaki, Kosuke Ichikawa, Satoshi Hokari, Rie Kondo, Masachika Hayashi, Hiroyuki Ishikawa, Takao Miyabayashi, Tetsuya Abe, Satoru Miura, Hiroshi Tanaka, Masaaki Okajima, Masaki Terada, Takashi Ishida, Akira Iwashima, Kazuhiro Sato, Hirohisa Yoshizawa, Nobumasa Aoki, Yasuyoshi Ohshima, Toshiyuki Koya, Toshiaki Kikuchi
Systemic immune-inflammation index is a stage-dependent prognostic factor in patients with operable non-small cell lung cancer
Fangqiu Fu, Chaoqiang Deng, Zhexu Wen, Zhendong Gao, Yue Zhao, Han Han, Shanbo Zheng, Shengping Wang, Yuan Li, Hong Hu, Yang Zhang, Haiquan Chen
Exosomal miR-375-3p breaks vascular barrier and promotes small cell lung cancer metastasis by targeting claudin-1
Shuangshuang Mao, Sufei Zheng, Zhiliang Lu, Xinfeng Wang, Yan Wang, Guochao Zhang, Haiyan Xu, Jianbing Huang, Yuanyuan Lei, Chengming Liu, Nan Sun, Jie He
Risk-score model to predict prognosis of malignant airway obstruction after interventional bronchoscopy
Minlin Jiang, Hao Xu, Dongmei Yu, Li Yang, Wenhui Wu, Hao Wang, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Liping Zhang, Likun Hou, Huixian Zhang, Ye Gu, Yayi He
Association of hepatitis B virus infection status with outcomes of non-small cell lung cancer patients undergoing anti-PD-1/PD-L1 therapy
Xuanye Zhang, Dan Tian, Yue Chen, Chen Chen, Li-Na He, Yixin Zhou, Haifeng Li, Zuan Lin, Tao Chen, Yuhong Wang, Alessandro Russo, Ernest Nadal, Francesco Passiglia, Ross Andrew Soo, Satoshi Watanabe, Teresa Moran, In-Jae Oh, Sha Fu, Shaodong Hong, Li Zhang
A simplified model for determining the cutting plane during thoracoscopic anatomical partial lobectomy of the right lower lobe
Yun Liu, Bin Qiu, Songlin Zhang, Chaobing Liu, Ming Yan, Lailong Sun, Dominique Gossot, Takahiro Homma, Fariha Sheikh, Peter J. Kneuertz
Detection of epidermal growth factor receptor (EGFR) mutations from preoperative circulating tumor DNA (ctDNA) as a prognostic predictor for stage I–III non-small cell lung cancer (NSCLC) patients with baseline tissue EGFR mutations
Kai Guo, Changjian Shao, Lu Han, Honggang Liu, Zhiqiang Ma, Yang Yang, Yingtong Feng, Minghong Pan, Mariacarmela Santarpia, Maria Carmo-Fonseca, Catarina Silveira, Kye Young Lee, Jing Han, Xiaofei Li, Xiaolong Yan
Breast metastases from primary lung cancer: a retrospective case series on clinical, ultrasonographic, and immunohistochemical features
Bo Wang, Ying Jiang, Shi Yu Li, Rui Lan Niu, Justin D. Blasberg, Jussuf T. Kaifi, Gang Liu, Zhi Li Wang
Serum tumor markers for the prediction of concordance between genomic profiles from liquid and tissue biopsy in patients with advanced lung adenocarcinoma
Xiao-Dong Jiao, Li-Ren Ding, Chuan-Tao Zhang, Bao-Dong Qin, Ke Liu, Lian-Ping Jiang, Xi Wang, Li-Ting Lv, Hao Ding, Dao-Ming Li, Hui Yang, Xue-Qin Chen, Wen-Yu Zhu, Ying Wu, Yan Ling, Xi He, Jun Liu, Lin Shao, Hao-Zhe Wang, Yan Chen, Jing-Jing Zheng, Naoki Inui, Yuan-Sheng Zang
The prognostic role of the Transducin-like Enhancer of split protein family in lung adenocarcinoma
Qianli Ma, Fei Xiao, Yang Hao, Zhiyi Song, Jin Zhang, Chaozeng Si, Chaoyang Liang, Deruo Liu

Review Article

A narrative review of primary research endpoints of neoadjuvant therapy for lung cancer: past, present and future
Sijia Ren, Anyi Xu, Yilian Lin, D. Ross Camidge, Massimo Di Maio, Raffaele Califano, Toyoaki Hida, Antonio Rossi, Nicolas Guibert, Chengchu Zhu, Jianfei Shen
Hyperprogression under immunotherapy: a new form of immunotherapy response?—a narrative literature review
Miaozhen Lin, Ben G. L. Vanneste, Qiwen Yu, Zebin Chen, Jiayu Peng, Xiuyu Cai

Case Report

Adrenal crisis and acute exacerbation of interstitial lung disease after thymoma needle biopsy: a case report and literature review
Hengyi Yan, Qi Qi, Kai Zhang, Bing He, Guoming Chu, Guan Wang, Hua Wen, Yanyan Zhao, Hongxu Liu, Li Zhao, Yu Chen
Acute anti-Ma2 paraneoplastic encephalitis associated to pembrolizumab: a case report and review of literature
Víctor Albarrán, Javier Pozas, Fernando Rodríguez, Ángela Carrasco, Elena Corral, Yolanda Lage, Pablo Álvarez-Ballesteros, Ainara Soria, Pilar Garrido
Mobile 3-dimensional (3D) C-arm system-assisted transbronchial biopsy and ablation for ground-glass opacity pulmonary nodules: a case report
Junxiang Chen, Fangfang Xie, Xiaoxuan Zheng, Ying Li, Shuaiyang Liu, Kevin C. Ma, Taichiro Goto, Tobias Müller, Edward D. Chan, Jiayuan Sun

Editorial on Oligometastatic NSCLC: Definition and Treatment Opportunities1

Oligometastatic non-small cell lung cancer: from biology to clinical practice
Maurizio V. Infante, Thierry Berghmans
Local for advanced, is this a paradox?
Maristella Bungaro, Chiara Paratore, Paolo Bironzo, Silvia Novello

Review Article on Oligometastatic NSCLC: Definition and Treatment Opportunities1

Defining oligometastatic non-small cell lung cancer: concept versus biology, a literature review
Jill F. Mentink, Marthe S. Paats, Daphne W. Dumoulin, Robin Cornelissen, Joris B. W. Elbers, Alexander P. W. M. Maat, Jan H. von der Thüsen, Anne-Marie C. Dingemans
Epidemiology of oligometastatic non-small cell lung cancer: results from a systematic review and pooled analysis
Elisa Gobbini, Luca Bertolaccini, Niccolò Giaj-Levra, Jessica Menis, Matteo Giaj-Levra
Narrative review: molecular and genetic profiling of oligometastatic non-small cell lung cancer
Sawsan Rashdan, Puneeth Iyengar, John D. Minna, David E. Gerber
A narrative review on tumor microenvironment in oligometastatic and oligoprogressive non-small cell lung cancer: a lot remains to be done
Lorenzo Belluomini, Alessandra Dodi, Alberto Caldart, Dzenete Kadrija, Marco Sposito, Miriam Casali, Giulia Sartori, Miriam Grazia Ferrara, Alice Avancini, Emilio Bria, Jessica Menis, Michele Milella, Sara Pilotto
Diagnostic and prognostic biomarkers in oligometastatic non-small cell lung cancer: a literature review
Diego Cortinovis, Umberto Malapelle, Fabio Pagni, Alessandro Russo, Giuseppe Luigi Banna, Elisa Sala, Christian Rolfo
Clinical prognostic factors in surgically treated oligometastatic non-small cell lung cancer: a systematic review
Luca Bertolaccini, Monica Casiraghi, Giulia Sedda, Filippo de Marinis, Lorenzo Spaggiari
The role of the surgeon in the management of oligometastatic non-small cell lung cancer: a literature review
Lawek Berzenji, Sophie Debaenst, Jeroen M. H. Hendriks, Suresh Krishan Yogeswaran, Patrick Lauwers, Paul E. Van Schil
Radiotherapy for oligometastatic non-small cell lung cancer: a narrative review
Nora Sundahl, Yolande Lievens
Alternative methods for local ablation—interventional pulmonology: a narrative review
Gerard Olive, Rex Yung, Henry Marshall, Kwun M. Fong
Local ablative therapies in oligometastatic NSCLC-upfront or outback?—a narrative review
Michael C. Tjong, Alexander V. Louie, Puneeth Iyengar, Benjamin J. Solomon, David A. Palma, Shankar Siva
Local ablative therapy in oncogenic-driven oligometastatic non-small cell lung cancer: present and ongoing strategies—a narrative review
Vincent Fallet, Lise Matton, Antoine Schernberg, Anthony Canellas, François H. Cornelis, Jacques Cadranel
Current and future research efforts in oligometastatic non-small cell lung cancer—a systematic review
Mariana Brandão, Valérie Durieux, Thierry Berghmans
How to optimize the incorporation of immunotherapy in trials for oligometastatic non-small cell lung cancer: a narrative review
Jordi Remon, Jessica Menis, Antonin Levy, Dirk K. M. De Ruysscher, Lizza E. L. Hendriks

Disclosure:

1. The series “Oligometastatic NSCLC: definition and treatment opportunities” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Maurizio V. Infante and Thierry Berghmans served as the unpaid Guest Editors for the series.

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article