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Original Article

Comprehensive analysis of blood-based biomarkers for predicting immunotherapy benefits in patients with advanced non-small cell lung cancer
Cheol-Kyu Park, Hyung-Joo Oh, Min-Seok Kim, Bo-Gun Koh, Hyun-Ju Cho, Young-Chul Kim, Hyung-Jeong Yang, Ji-Young Lee, Sung-Min Chun, In-Jae Oh
Earlier extracranial progression and shorter survival in ALK- rearranged lung cancer with positive liquid rebiopsies
Petros Christopoulos, Steffen Dietz, Arlou K. Angeles, Stephan Rheinheimer, Daniel Kazdal, Anna-Lena Volckmar, Florian Janke, Volker Endris, Michael Meister, Mark Kriegsmann, Thomasz Zemojtel, Martin Reck, Albrecht Stenzinger, Michael Thomas, Holger Sültmann
Characteristics of hypoxic tumor microenvironment in non-small cell lung cancer, involving molecular patterns and prognostic signature
Zhanghao Huang, Shuo Wang, Hai-Jian Zhang, You Lang Zhou, Xin Tang, Jia-Hai Shi
Impact of chronic obstructive pulmonary disease on immune checkpoint inhibitor efficacy in advanced lung cancer and the potential prognostic factors
Jiebai Zhou, Yencheng Chao, Danwei Yao, Ning Ding, Jiamin Li, Lei Gao, Yong Zhang, Xiaobo Xu, Jian Zhou, Balazs Halmos, Nikolaos Tsoukalas, Yuki Kataoka, Ramon Andrade de Mello, Yuanlin Song, Jie Hu
A nomogram to predict the overall survival of patients with symptomatic extensive-stage small cell lung cancer treated with thoracic radiotherapy
Xun Yuan, Zhiqin Zheng, Fangfang Liu, Yuan Gao, Wenhui Zhang, Rossana Berardi, Pranshu Mohindra, Zhengfei Zhu, Jie Lin, Qian Chu
M5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in lung adenocarcinoma
Hui Chen, Xiao-Lin Ge, Zhao-Yue Zhang, Ming Liu, Rui-Yan Wu, Xiao-Fei Zhang, Li-Ping Xu, Hong-Yan Cheng, Xin-Chen Sun, Hong-Cheng Zhu
Neoadjuvant chemoimmunotherapy in resectable stage IIIA/IIIB non-small cell lung cancer
Yulong Chen, Bo Yan, Feng Xu, Zhenzhen Hui, Gang Zhao, Jie Liu, Huan Zhang, Ziqing Zeng, Ran Zhang, Mariano Provencio, Xiubao Ren, Jian You
Risk stratification model for patients with stage I invasive lung adenocarcinoma based on clinical and pathological predictors
Yiyang Wang, Difan Zheng, Jizhuang Luo, Jie Zhang, Cecilia Pompili, Hideki Ujiie, Natsumi Matsuura, Haiquan Chen, Feng Yao
Hybrid stenting with silicone Y stents and metallic stents in the management of severe malignant airway stenosis and fistulas
Yu Chen, Zi-Qing Zhou, Jia-Xin Feng, Zhu-Quan Su, Chang-Hao Zhong, Li-Ya Lu, Xiao-Bo Chen, Chun-Li Tang, Subba R. Digumarthy, Alfonso Fiorelli, Ehsan Natour, Filippo Lococo, Francesco Petrella, Kassem Harris, Takeo Nakada, Nan-Shan Zhong, Shi-Yue Li
Preoperative computer tomography-guided indocyanine green injection is associated with successful localization of small pulmonary nodules
Xukai Li, Ke Xu, Renli Cen, Jinghui Deng, Zhexue Hao, Jun Liu, Hiromitsu Takizawa, Calvin S. H. Ng, Giuseppe Marulli, Min P. Kim, Fei Cui, Jianxing He

Editorial on Lung Cancer Screening1

Lung cancer screening: the preface
Annemiek Snoeckx, Paul E. Van Schil

Review Article on Lung Cancer Screening1

Lung cancer screening: targeting the hard to reach—a review
Guido Van Hal, Paloma Diab Garcia
Managing screening-detected subsolid nodules—the Asian perspective
Masaaki Sato, Shun-Mao Yang, Dong Tian, Nakajima Jun, Jang-Ming Lee
Screen-detected solid nodules: from detection of nodule to structured reporting
Mario Silva, Gianluca Milanese, Roberta E. Ledda, Ugo Pastorino, Nicola Sverzellati
Ongoing challenges in implementation of lung cancer screening
Katharina Martini, Guillaume Chassagnon, Thomas Frauenfelder, Marie-Pierre Revel
The radiologist’s role in lung cancer screening
Annemiek Snoeckx, Caro Franck, Mario Silva, Mathias Prokop, Cornelia Schaefer-Prokop, Marie-Pierre Revel
Managing of screening-detected sub-solid nodules—a European perspective
Sara Ricciardi, Richard Booton, Renè Horsleben Petersen, Maurizio Infante, Marco Scarci, Giulia Veronesi, Giuseppe Cardillo
Artificial intelligence for detection and characterization of pulmonary nodules in lung cancer CT screening: ready for practice?
Anton Schreuder, Ernst T. Scholten, Bram van Ginneken, Colin Jacobs
Lung cancer screening: who pays? who receives?—the Chinese perspective
Yang Zhang, Haiquan Chen
Lung cancer screening: who pays? Who receives? The European perspectives
Pierluigi Novellis, Silvia Raimondi Cominesi, Francesca Rossetti, Michele Mondoni, Vanesa Gregorc, Giulia Veronesi
Lung cancer screening in Europe: where are we in 2021?
Jan P. van Meerbeeck, Caro Franck
Should sublobar resection be offered for screening-detected lung nodules?
Alan D. L. Sihoe
The person behind the nodule: a narrative review of the psychological impact of lung cancer screening
Samantha L. Quaife, Samuel M. Janes, Kate E. Brain

Disclosure:

1. The series “Lung cancer screening” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Paul van Schil and Annemiek Snoeckx served as the unpaid Guest Editors for the series.

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article


Review Article


Editorial



Brief Report


Editorial on Lung Cancer and The Immune System


Editorial on Immunotherapy in Other Thoracic Malignancies and Uncommon Populations