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Original Article

Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study
Luka Brcic, Thomas Klikovits, Zsolt Megyesfalvi, Berta Mosleh, Katharina Sinn, Richard Hritcu, Viktoria Laszlo, Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic, Marko Jakopovic, Miroslav Samarzija, Sven Seiwerth, Vitezslav Kolek, Ondřej Fischer, Petr Jakubec, Jozef Škarda, Balazs Gieszer, Balazs Hegedus, Janos Fillinger, Ferenc Renyi-Vamos, Anna Buder, Agnes Bilecz, Walter Berger, Michael Grusch, Konrad Hoetzenecker, Walter Klepetko, Mir Alireza Hoda, Martin Filipits, Balazs Dome
Transbronchial microwave ablation of lung nodules with electromagnetic navigation bronchoscopy guidance—a novel technique and initial experience with 30 cases
Joyce W. Y. Chan, Rainbow W. H. Lau, Jenny C. L. Ngai, Carita Tsoi, Cheuk Man Chu, Tony S. K. Mok, Calvin S. H. Ng
Plasma pre-treatment T790M relative allelic frequency in patients with advanced EGFR-mutated non-small cell lung cancer predicts treatment response to subsequent-line osimertinib
Pei N. Ding, Tara L. Roberts, Wei Chua, Therese M. Becker, Nicole Caixeiro, Paul de Souza, Bo Gao, Chee K. Lee, Malinda Itchins, Helen Westman, Stephen Clarke, Prunella Blinman, Steven Kao, Tom John, Jose L. Leal, Victoria J. Bray
Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? —a prospective multi-center cohort study
Ting Ye, Zongwei Chen, Dongchun Ma, Sufeng Chen, Guozhan Xia, Yiliang Zhang, Hang Li, Yang Zhang, Xiaoyang Luo, Longsheng Miao, Longfei Ma, Yihua Sun, Yunjian Pan, Hong Hu, Yawei Zhang, Jiaqing Xiang, Longlong Shao, Haoxuan Wu, Bin Li, Qingyuan Huang, Xiao Ma, Difan Zheng, Shanbo Zheng, Chongze Yuan, Tao Yu, Yunyun Lu, Yuan Li, Qiao Li, Yajia Gu, Shengping Wang, Di Ge, Jie Gu, Feng Zhu, Jingshun Zhang, Fudong Wang, Yuan Weng, Chunyi Jia, Shilei Liu, Wenqun Xing, Kaihong Lin, Shaoqing Tang, Bin Qian, Michael Hsin, Haiquan Chen
Impact of docetaxel plus ramucirumab on metastatic site in previously treated patients with non-small cell lung cancer: a multicenter retrospective study
Kinnosuke Matsumoto, Akihiro Tamiya, Yoshinobu Matsuda, Yoshihiko Taniguchi, Shinji Atagi, Hayato Kawachi, Motohiro Tamiya, Satoshi Tanizaki, Junji Uchida, Kiyonobu Ueno, Takafumi Yanase, Hidekazu Suzuki, Tomonori Hirashima
EPAC-lung: European pooled analysis of the prognostic value of circulating tumour cells in small cell lung cancer
Victoria Foy, Colin R. Lindsay, Alexandra Carmel, Fabiola Fernandez-Gutierrez, Matthew G. Krebs, Lynsey Priest, Mathew Carter, Harry J. M. Groen, T. Jeroen. N. Hiltermann, Antonella de Luca, Francoise Farace, Benjamin Besse, Leon Terstappen, Elisabetta Rossi, Alessandro Morabito, Francesco Perrone, Andrew Renehan, Corinne Faivre-Finn, Nicola Normanno, Caroline Dive, Fiona Blackhall, Stefan Michiels
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma
Daniel Kazdal, Eugen Rempel, Cristiano Oliveira, Michael Allgäuer, Alexander Harms, Kerstin Singer, Elke Kohlwes, Steffen Ormanns, Ludger Fink, Jörg Kriegsmann, Michael Leichsenring, Katharina Kriegsmann, Fabian Stögbauer, Luca Tavernar, Jonas Leichsenring, Anna-Lena Volckmar, Rémi Longuespée, Hauke Winter, Martin Eichhorn, Claus Peter Heußel, Felix Herth, Petros Christopoulos, Martin Reck, Thomas Muley, Wilko Weichert, Jan Budczies, Michael Thomas, Solange Peters, Arne Warth, Peter Schirmacher, Albrecht Stenzinger, Mark Kriegsmann
Identification of PD-1 ligands: PD-L1 and PD-L2 on macrophages in lung cancer milieu by flow cytometry
Iwona Kwiecień, Elżbieta Rutkowska, Małgorzata Polubiec-Kownacka, Agata Raniszewska, Piotr Rzepecki, Joanna Domagała-Kulawik
A nomogram for predicting overall survival in patients with resected non-small cell lung cancer treated with chemotherapy
Yuan Zeng, Nicholas Mayne, Chi-Fu Jeffrey Yang, Jun Liu, Fei Cui, Jingpei Li, Wenhua Liang, Jianxing He, written on behalf of the AME Thoracic Surgery Collaborative Group
Blood transfusions may adversely affect survival outcomes of patients with lung cancer: a systematic review and meta-analysis
Sukjoo Cho, Jonghanne Park, Misuk Lee, Dongyup Lee, Horyun Choi, Gahyun Gim, Leeseul Kim, Cyra Y. Kang, Youjin Oh, Pedro Viveiros, Elena Vagia, Michael S. Oh, Geum Joon Cho, Ankit Bharat, Young Kwang Chae
Watershed analysis of the target pulmonary artery for real-time localization of non-palpable pulmonary nodules
Xiang-Peng Chu, Zi-Hao Chen, Shao-Min Lin, Jia-Tao Zhang, Zhao-Wen Qiu, Wen-Fang Tang, Rui Fu, Zhen-Bin Qiu, Xue-Ning Yang, Yi-Long Wu, Qiang Nie, Wen-Zhao Zhong
Age at first birth and lung cancer: a two-sample Mendelian randomization study
Haoxin Peng, Xiangrong Wu, Yaokai Wen, Xiaoqin Du, Caichen Li, Hengrui Liang, Jinsheng Lin, Jun Liu, Fan Ge, Zhenyu Huo, Jianxing He, Wenhua Liang
Presentation of EGFR mutations in 162 family probands with multiple primary lung cancer
Chunxiang Li, Yalong Wang, Kai Su, Yu Liu, Liyu Wang, Bo Zheng, Na Yan, Dawei Yuan, Yanxiang Zhang, Liyan Xue, Shugeng Gao, Jie He
Distinct patterns of somatic genomic alterations and mutational signatures in central and peripheral-type small-cell lung cancer
Lei Wang, Jing Wang, Juanni Hu, Lele Song, Jian Ni, Yayi He, Caicun Zhou
Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
José Ramón Jarabo Sarceda, Sergio Bolufer Nadal, Roberto Mongil Poce, Pedro López de Castro, Ramón Moreno Balsalobre, Juan Carlos Peñalver Cuesta, Raul Embún Flor, Joaquín Pac Ferrer, Francisco Javier Algar Algar, Antonio Pablo Gámez García, Marcelo F. Jiménez, Jesús Gabriel Sales-Badía, Eva Pereira, Bartomeu Massuti, Mariano Provencio, Florentino Hernando Trancho
MicroRNA expression profiling and biomarker validation in treatment-naïve and drug resistant non-small cell lung cancer
Lauren MacDonagh, Michael F. Gallagher, Brendan Ffrench, Claudia Gasch, Steven G. Gray, Marie Reidy, Siobhan Nicholson, Niamh Leonard, Ronan Ryan, Vincent Young, John J. O’Leary, Sinead Cuffe, Stephen P. Finn, Kenneth J. O’Byrne, Martin P. Barr
Genomic evolutionary trajectory of metastatic squamous cell carcinoma of the lung
Arthur Krause, Luca Roma, Thomas Lorber, Tanja Dietsche, Valeria Perrina, David C. Müller, Didier Lardinois, Christian Ruiz, Spasenija Savic Prince, Salvatore Piscuoglio, Charlotte KY Ng, Lukas Bubendorf
Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer
Jara Martín, Joan Josep Castellano, Ramón María Marrades, Jordi Canals, Nuria Viñolas, Tania Díaz, Laureano Molins, Daniel Martinez, Bing Han, Jorge Moisés, Yangyi He, Mariano Monzó, Alfons Navarro
Safety and efficacy of anti-PD-1 inhibitors in Chinese patients with advanced lung cancer and hepatitis B virus infection: a retrospective single-center study
Fei Xu, Zhu Zeng, Bing Yan, Yiqi Fu, Yilan Sun, Guangdie Yang, Lingfang Tu, Satoshi Watanabe, Salma K. Jabbour, Sara Bravaccini, Francesca Fanini, Jianying Zhou, Yihong Shen
Derivation and validation of a nomogram model for pulmonary thromboembolism in patients undergoing lung cancer surgery
Yuping Li, Lei Shen, Junrong Ding, Dong Xie, Jian Yang, Yanfeng Zhao, Angelo Carretta, René Horsleben Petersen, Sebastien Gilbert, Yasuhiro Hida, Servet Bölükbas, Hiran C. Fernando, Gening Jiang, Yuming Zhu
Let-7b-3p inhibits tumor growth and metastasis by targeting the BRF2-mediated MAPK/ERK pathway in human lung adenocarcinoma
Yongmeng Li, Rui Dong, Ming Lu, Chuanle Cheng, Zitong Feng, Renchang Zhao, Jinghui Liang, Jingyi Han, Jin Jiang, Meng Xu-Welliver, Stéphane Renaud, Hui Tian
Targeting histone deacetylase enhances the therapeutic effect of Erastin-induced ferroptosis in EGFR-activating mutant lung adenocarcinoma
Tuo Zhang, Beibei Sun, Chenxi Zhong, Ke Xu, Zhexin Wang, Paul Hofman, Tatsuya Nagano, Antoine Legras, Daniel Breadner, Biagio Ricciuti, Duilio Divisi, Ralph A. Schmid, Ren-Wang Peng, Haitang Yang, Feng Yao
Anlotinib combined with gefitinib can significantly improve the proliferation of epidermal growth factor receptor-mutant advanced non-small cell lung cancer in vitro and in vivo
Tao Li, Yuxian Qian, Chenfei Zhang, Junji Uchino, Mariano Provencio, Yan Wang, Xiangrong Shi, Yan Zhang, Xiaodong Zhang

Editorial on Radiotherapy in Thoracic Malignancies1

Radiotherapy in thoracic malignancies: the preface
Jacek Jassem, Rafał Dziadziuszko

Review Article on Radiotherapy in Thoracic Malignancies1

Stereotactic radiotherapy for early stage non-small cell lung cancer: current standards and ongoing research
Eugenia Vlaskou Badra, Michael Baumgartl, Silvia Fabiano, Aurélien Jongen, Matthias Guckenberger
Preoperative and postoperative radiotherapy (RT) for non-small cell lung cancer: still an open question
Paul Van Houtte, Luigi Moretti, Florian Charlier, Martine Roelandts, Dirk Van Gestel

Original Article on Radiotherapy in Thoracic Malignancies1

Stage III N2 non-small cell lung cancer treatment: decision-making among surgeons and radiation oncologists
Markus Glatzer, Pawel Leskow, Francesca Caparrotti, Olgun Elicin, Markus Furrer, Franco Gambazzi, André Dutly, Hans Gelpke, Matthias Guckenberger, Jürg Heuberger, Rolf Inderbitzi, Stefano Cafarotti, Wolfram Karenovics, Peter Kestenholz, Gregor Jan Kocher, Peter Kraxner, Thorsten Krueger, Francesco Martucci, Christoph Oehler, Mahmut Ozsahin, Alexandros Papachristofilou, Dirk Wagnetz, Kathrin Zaugg, Daniel Zwahlen, Isabelle Opitz, Paul Martin Putora

Review Article on Radiotherapy in Thoracic Malignancies1

Dose and fractionation schedules in radiotherapy for non-small cell lung cancer
Lucyna Kepka, Joanna Socha
Challenges in the target volume definition of lung cancer radiotherapy
Susan Mercieca, José S. A. Belderbos, Marcel van Herk
Evolving target volume concepts in locally advanced non-small cell lung cancer
Ursula Nestle, Cecile Le Pechoux, Dirk De Ruysscher
Tumour motion management in lung cancer: a narrative review
Angela Botticella, Antonin Levy, Guillaume Auzac, Isabelle Chabert, Céline Berthold, Cécile Le Pechoux
Concurrent chemoradiotherapy for stage III non-small-cell lung cancer: recent progress and future perspectives (a narrative review)
Małgorzata Łazar-Poniatowska, Artur Bandura, Rafał Dziadziuszko, Jacek Jassem
Combining radiotherapy with targeted therapies in non-small cell lung cancer: focus on anti-EGFR, anti-ALK and anti-angiogenic agents
Anna Wrona, Rafał Dziadziuszko, Jacek Jassem
An overview of the published and running randomized phase 3 clinical results of radiotherapy in combination with immunotherapy
Ben G. L. Vanneste, Evert J. Van Limbergen, Kobe Reynders, Dirk De Ruysscher
Thoracic radiotherapy in small cell lung cancer—a narrative review
Antonin Levy, Angela Botticella, Cécile Le Péchoux, Corinne Faivre-Finn
Prophylactic cranial irradiation in SCLC
Rafal Suwinski
Controversies in the role of radiotherapy in pleural mesothelioma
Gerard G. Hanna, Thomas John, David L. Ball
Radiotherapy for thymic epithelial tumours: a review
Krisztian Süveg, Paul Martin Putora, Markus Joerger, Thomas Iseli, Galina Farina Fischer, Karlheinz Ammann, Markus Glatzer

Disclosure:

1. The series “Oligometastatic NSCLC: definition and treatment opportunities” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Jacek Jassem and Rafał Dziadziuszko served as the unpaid Guest Editors for the series.

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article


Review Article


Editorial