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Original Article

Nivolumab in pre-treated advanced non-small cell lung cancer: long term follow up data from the Dutch expanded access program and routine clinical care
Robert D. Schouten, Lucie Egberink, Mirte Muller, Cornedine J. De Gooijer, Erik van Werkhoven, Michel M. van den Heuvel, Paul Baas
The different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer
Hyun Ae Jung, Sook Young Woo, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples
Herbert Ho-Fung Loong, Nan Du, Chunyan Cheng, Hanqing Lin, Jian Guo, Gen Lin, Mingjiang Li, Tao Jiang, Zhihua Shi, Yanzhi Cui, Xianfeng Jin, Jicheng Yao, Yutong Xing, Ming Yao, Kai Wang, Tony S. K. Mok, Lunxu Liu
The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis
Bin Wu, Shun Lu
Treatments for combined small cell lung cancer patients
Jiaxi He, Songhui Xu, Hui Pan, Shuben Li, Jianxing He
Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer
Joanna Kapeleris, Arutha Kulasinghe, Majid Ebrahimi Warkiani, Connor Oleary, Ian Vela, Paul Leo, Peter Sternes, Kenneth O’Byrne, Chamindie Punyadeera
SRC and PIM1 as potential co-targets to overcome resistance in MET deregulated non-small cell lung cancer
Ilaria Attili, Laura Bonanno, Niki Karachaliou, Jillian Wilhelmina Paulina Bracht, Jordi Berenguer, Carles Codony-Servat, Jordi Codony-Servat, Erika Aldeguer, Ana Gimenez-Capitan, Alessandro Dal Maso, Matteo Fassan, Imane Chaib, Miguel Angel Molina-Vila, Antonio Passaro, Filippo de Marinis, Giulia Pasello, Valentina Guarneri, Pier Franco Conte, Rafael Rosell
Significant diaphragm elevation suggestive of phrenic nerve injury after thoracoscopic lobectomy for lung cancer: an underestimated problem
Luigi Ventura, Weigang Zhao, Tangbing Chen, Zhexin Wang, Jian Feng, Zhitao Gu, Chunyu Ji, Wentao Fang
Interactions between the enhanced recovery after surgery pathway and risk factors for lung infections after pulmonary malignancy operation
Xianfei Zhang, Runsen Jin, Yuyan Zheng, Dingpei Han, Kai Chen, Jian Li, Hecheng Li
Establishment and validation of a mathematical diagnosis model to distinguish benign pulmonary nodules from early non-small cell lung cancer in Chinese people
Qiang Wei, Weizhen Fang, Xi Chen, Zhongzhen Yuan, Yumei Du, Yanbin Chang, Yonghong Wang, Shulin Chen
Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with EGFR exon 20 insertion mutation: a multicenter study
Chun-Wei Xu, Wen-Xian Wang, Dong Wang, Qi-Ming Wang, Xing-Xiang Pu, You-Cai Zhu, Jian-Hui Huang, Zong-Yang Yu, Zhao-Lei Cui, Xiao-Hui Chen, Jin-Luan Li, Yong Fang, Hong Wang, Wu Zhuang, Shi-Jie Lan, Xin Cai, Yin-Bin Zhang, Wen-Bin Gao, Li-Ping Wang, Ke-Lin She, Chuang-Zhou Rao, Yue-Fen Zhou, Mei-Yu Fang, Li-Yun Miao, Lei Lei, Tang-Feng Lv, Yong Song, on behalf of AME Lung Cancer Collaborative Group
Stereotactic body radiation therapy for empirically treated hypermetabolic lung lesions: a single-institutional experience identifying the Charlson score as a key prognostic factor
Roman O. Kowalchuk, Michael R. Waters, Sujith Baliga, K. Martin Richardson, Kelly M. Spencer, James M. Larner, Charles R. Kersh
Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer
Gloria Y. F. Ho, Tao Wang, Hoi-Hin Kwok, Rehana Rasul, Rita Peila, Maria Guzman, Mary S. M. Ip, David C. L. Lam
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma
Chaoyang Liang, Xiaowei Wang, Zhenrong Zhang, Fei Xiao, Hongxiang Feng, Qianli Ma, Jingjing Huang, Guangliang Qiang, Dingrong Zhong, Deruo Liu
Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells
Michelle Simone Clement, Kristine Raaby Gammelgaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Prognostic implications of preoperative versus postoperative circulating tumor DNA in surgically resected lung cancer patients: a pilot study
Shuta Ohara, Kenichi Suda, Kazuko Sakai, Masaya Nishino, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Toshio Fujino, Takamasa Koga, Akira Hamada, Junichi Soh, Kazuto Nishio, Tetsuya Mitsudomi
How long is cessation of preoperative smoking required to improve postoperative survival of patients with pathological stage I non-small cell lung cancer?
Toshiyuki Shima, Tomonari Kinoshita, Mao Uematsu, Naomichi Sasaki, Yusuke Sugita, Reiko Shimizu, Masahiko Harada, Tsunekazu Hishima, Hirotoshi Horio
SMO mutations confer poor prognosis in malignant pleural mesothelioma
Diego Signorelli, Claudia Proto, Laura Botta, Annalisa Trama, Marcello Tiseo, Giulia Pasello, Giuseppe Lo Russo, Alessandra Fabbri, Martina Imbimbo, Adele Busico, Arsela Prelaj, Roberto Ferrara, Giulia Galli, Alessandro De Toma, Elena Tamborini, Ugo Pastorino, Filippo de Braud, Gemma Gatta, Marina Chiara Garassino, Monica Ganzinelli
Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib
Ye Wang, Yanqi He, Panwen Tian, Weiya Wang, Ke Wang, Shannon Chuai, Yalun Li, Shuang Zhao, Yu Wang, Weimin Li
A pilot study of the ultrathin cryoprobe in the diagnosis of peripheral pulmonary ground-glass opacity lesions
Simin Jiang, Xiaojun Liu, Junxiang Chen, Haifeng Ma, Fangfang Xie, Jiayuan Sun
Enumeration and molecular characterization of circulating tumor cells enriched by microcavity array from stage III non-small cell lung cancer patients
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Wei Qiao, Suyu Liu, Jianzhong He, Yawei Qiao, Luyang Yao, Steven H. Lin, James M. Reuben
Is clinical target volume necessary?—a failure pattern analysis in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy using intensity-modulated radiotherapy technique
Liqing Zou, Li Chu, Fan Xia, Lijun Zhou, Xi Yang, Jianjiao Ni, Junchao Chen, Zhengfei Zhu
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio associations with heart and body dose and their effects on patient outcomes in locally advanced non-small cell lung cancer treated with definitive radiotherapy
Wu-Yan Xia, Xue-Ru Zhu, Wen Feng, Jun Liu, Jia-Ming Wang, Chang-Xing Lv, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu

Study Protocol

GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/ unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy
Qing Zhou, Ming Chen, Gang Wu, Jian-Hua Chang, Ou Jiang, Jiu-Wei Cui, Guang Han, Qin Lin, Jian Fang, Gong-Yan Chen, Yi-Long Wu
Evaluating the diagnostic accuracy of a ctDNA methylation classifier for incidental lung nodules: protocol for a prospective, observational, and multicenter clinical trial of 10,560 cases
Wenhua Liang, Dan Liu, Min Li, Wei Wang, Zheng Qin, Jian Zhang, Yong Zhang, Yang Hu, Hairong Bao, Yi Xiang, Bo Wang, Jing Wu, Jianyu Sun, Chengping Hu, Xianwei Ye, Xiangyan Zhang, Wei Xiao, Chunmei Yun, Dejun Sun, Wei Wang, Ning Chang, Yunhui Zhang, Jianping Zhao, Xin Zhang, Jinfu Xu, Di Wu, Xiaoju Liu, Yubiao Guo, Qichuan Zhang, Wei Zhang, Lan Yang, Zhanqing Li, Xiaoju Zhang, Baohui Han, Zhaohui Tong, Jianxing He, Jieming Qu, Jian-Bing Fan, Nanshan Zhong

Technical Note

Dynamic titanium prosthesis based on 3D-printed replica for chest wall resection and reconstruction
Jacopo Vannucci, Elisa Scarnecchia, Rossella Potenza, Silvia Ceccarelli, Donato Monopoli, Francesco Puma

Review Article

Optimizing current standard of care therapy for stage III non-small cell lung cancer
Vivek Verma, Steven H. Lin
A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer
Rahul N. Prasad, Terence M. Williams
Narrative review of the emerging role of molecular biomarkers in guiding the definitive management of unresectable non-small cell lung cancer
Eric K. Singhi, Carl M. Gay
Treatment of stage III non-small cell lung cancer in the era of immunotherapy: pathological complete response to neoadjuvant pembrolizumab and chemotherapy
Zhang-Ru Yang, Mi-Na Liu, Jia-Hua Yu, Yun-Hai Yang, Tian-Xiang Chen, Yu-Chen Han, Lei Zhu, Ji-Kai Zhao, Xiao-Long Fu, Xu-Wei Cai
A narrative review of lung cancer cytology in the times of coronavirus: what physicians should know
Pasquale Pisapia, Umberto Malapelle, Maria Salatiello, Rafael Rosell, Giancarlo Troncone
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy
Shuyan Li, Xiao Chu, Luxi Ye, Jianjiao Ni, Zhengfei Zhu
Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy
Tiantian Guo, Liqing Zou, Jianjiao Ni, Xiao Chu, Zhengfei Zhu
A narrative review of biosimilars: a continued journey from the scientific evidence to practice implementation
Jorge J. García, Luis E. Raez, Daniel Rosas
Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge—a narrative review
Wu-Yan Xia, Wen Feng, Chen-Chen Zhang, Yu-Jia Shen, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu
Perspective on treatment for unresectable locally advanced non-small cell lung cancer with oncogene-driven mutation: a narrative review
Liyang Jiang, Xiangjiao Meng, Xianguang Zhao, Ligang Xing, Jinming Yu

Disclosure:

1. The series “New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Helmut Popper served as the unpaid Guest Editor for the series.

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article


Review Article



Case Report