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Original Article

Detection and quantification of EGFR T790M mutation in liquid biopsies by droplet digital PCR
Catarina Silveira, Ana Carla Sousa, André Janeiro, Sara Malveiro, Encarnação Teixeira, Eva Brysch, Marcos Pantarotto, Margarida Felizardo, Rosa Madureira, Fernando Nogueira, Cátia Guimarães, Cristina Matos, Dolores Canário, Jácome Bruges-Armas, Maria Carmo-Fonseca
Timing of chronic obstructive pulmonary disease diagnosis in lung cancer prognosis: a clinical and genomic-based study
Jie Dai, Yanqi He, Kunlatida Maneenil, Han Liu, Ming Liu, Qian Guo, Amy C. Bennett, Shawn M. Stoddard, Jason A. Wampfler, Gening Jiang, Ping Yang
Low-level expression of necroptosis factors indicates a poor prognosis of the squamous cell carcinoma subtype of non-small-cell lung cancer
Jun Hyeok Lim, Sekyung Oh, Lucia Kim, Young Ju Suh, Yu-Jin Ha, Jung Soo Kim, Hyun-Jung Kim, Mi Hwa Park, Young Sam Kim, Yunjung Cho, Seung Min Kwak, Hong Lyeol Lee, You-Sun Kim, Jeong-Seon Ryu
Effect of prior therapy on tumor mutational burden in NSCLC
Sushma Jonna, Ari Vanderwalde, Jorge Nieva, Kelsey Anne Poorman, Michelle Saul, Xinyu von Buttlar, John Y. Hu, Stephen V. Liu
Deep sequencing reveals the genomic characteristics of lung adenocarcinoma presenting as ground-glass nodules (GGNs)
Nan Wu, Sixue Liu, Jingjing Li, Zhenyu Hu, Shi Yan, Hongwei Duan, Dafei Wu, Yuanyuan Ma, Shaolei Li, Xing Wang, Yaqi Wang, Xiang Li, Xuemei Lu
Titin mutation in circulatory tumor DNA is associated with efficacy to immune checkpoint blockade in advanced non-small cell lung cancer
Chunxia Su, Xinxin Wang, Juan Zhou, Jing Zhao, Fei Zhou, Guodong Zhao, Xiaohong Xu, Xuan Zou, Bo Zhu, Qingzhu Jia
Inhaled corticosteroids and risk of lung cancer among chronic obstructive pulmonary disease patients: a comprehensive analysis of nine prospective cohorts
Fan Ge, Yi Feng, Zhenyu Huo, Caichen Li, Runchen Wang, Yaokai Wen, Sirui Gao, Haoxin Peng, Xiangrong Wu, Hengrui Liang, Bo Cheng, Ran Zhong, Jianxing He, Wenhua Liang
Concurrent use of metformin enhances the efficacy of EGFR-TKIs in patients with advanced EGFR-mutant non-small cell lung cancer—an option for overcoming EGFR-TKI resistance
Ruoshuang Han, Yijun Jia, Xuefei Li, Chao Zhao, Sha Zhao, Sangtian Liu, Yiwei Liu, Donglai Chen, Qian Zhang, Xiaozhen Liu, Jinpeng Shi, Jiayu Li, Caicun Zhou
Comprehensive molecular analysis of genomic profiles and PD-L1 expression in lung adenocarcinoma with a high-grade fetal adenocarcinoma component
Masaki Suzuki, Rika Kasajima, Tomoyuki Yokose, Hiroyuki Ito, Eigo Shimizu, Seira Hatakeyama, Kazuaki Yokoyama, Rui Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Emi Yoshioka, Kota Washimi, Yoichiro Okubo, Kae Kawachi, Shinya Sato, Yohei Miyagi
Validation of multivariable lung cancer risk prediction models for the personalized assignment of optimal screening frequency: a retrospective analysis of data from the German Lung Cancer Screening Intervention Trial (LUSI)
Sandra González Maldonado, Lucas Cory Hynes, Erna Motsch, Claus-Peter Heussel, Hans-Ulrich Kauczor, Hilary A. Robbins, Stefan Delorme, Rudolf Kaaks
Development of RECLS score to predict survival in lung cancer patients with malignant pleural effusion
Tianli Zhang, Xi Chen, Bing Wan, Yangyang Xu, Hongbing Liu, Tangfeng Lv, Ping Zhan, Yong Song
Whole exome sequencing characterization of individuals presenting extreme phenotypes of high and low risk of developing tobacco-induced lung adenocarcinoma
Ana Patiño-García, Elizabeth Guruceaga, Victor Segura, Rodrigo Sánchez Bayona, Maria Pilar Andueza, Ibon Tamayo Uria, Guillermo Serrano, Juan Pablo Fusco, María José Pajares, Alfonso Gurpide, Marimar Ocón, Miguel F. Sanmamed, Maria Rodriguez Ruiz, Ignacio Melero, Maria Dolores Lozano, Carlos de Andrea, Guillermo Pita, Anna Gonzalez-Neira, Alvaro Gonzalez, Javier J. Zulueta, Luis M. Montuenga, Ruben Pio, Jose Luis Perez-Gracia
Tumor-associated macrophages secret exosomal miR-155 and miR-196a-5p to promote metastasis of non-small-cell lung cancer
Xiang Li, Zhipeng Chen, Yaojun Ni, Chengyu Bian, Jingjing Huang, Liang Chen, Xueying Xie, Jun Wang
Public opinion on implementing the National Lung Cancer Screening Program in Korea
Junli Park, Jaeho Lee, Yeol Kim
Examining the diagnostic pathway for lung cancer patients in Wales using discrete event simulation
Tracey J. England, Paul R. Harper, Tom Crosby, Daniel Gartner, Edilson F. Arruda, Kieran G. Foley, Ian J. Williamson
HER2 transmembrane domain mutation: comprehensive characteristics and real-world evidence of treatment response in Chinese lung adenocarcinoma
Ziqi Jia, Jiahua Xing, Ji Li, Weiwei Wang, Yadong Wang, Yang Song, Xiaoying Yang, Jianchao Xue, Junyi Ye, Bing Li, Han Han-Zhang, Jiaxing Zhao, Xiaochun Zhang, Feng Peng, Fengxia Chen, Xueqin Chen, Yan Lu, Shenpeng Ying, Dongping Wu, Xinwei Zhang, Caixia Ma, Lipeng Lai, Songling Ma, Dianjing Liang, Peng Liu, Xiaoguang Li, Naixin Liang, Shanqing Li
Prognostic value of baseline and change in neutrophil-to-lymphocyte ratio for survival in advanced non-small cell lung cancer patients with poor performance status receiving PD-1 inhibitors
Shixue Chen, Ruixin Li, Zhibo Zhang, Ziwei Huang, Pengfei Cui, Wangping Jia, Sujie Zhang, Haitao Tao, Lijie Wang, Xiaoyan Li, Jinliang Wang, Junxun Ma, Zhefeng Liu, Di Huang, Xuan Zheng, Yuichi Saito, Yoshinobu Ichiki, Yi Hu
Surgery for advanced-stage non-small cell lung cancer: lobectomy or sub-lobar resection?
Zhexue Hao, Hengrui Liang, Yichi Zhang, Wei Wei, Yuting Lan, Shuxian Qiu, Guo Lin, Runchen Wang, Yulin Liu, Yingying Chen, Jun Huang, Wei Wang, Fei Cui, Taichiro Goto, Jin Yong Jeong, Giulia Veronesi, Alberto Lopez-Pastorini, Hitoshi Igai, Wenhua Liang, Jianxing He, Jun Liu
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition
Qiqi Liu, Yuying Hao, Rui Du, Dan Hu, Jian Xie, Jingxin Zhang, Guodong Deng, Ning Liang, Tiantian Tian, Lukas Käsmann, Dirk Rades, Chai Hong Rim, Pingping Hu, Jiandong Zhang
Isochorismatase domain-containing protein 1 (ISOC1) participates in DNA damage repair and inflammation-related pathways to promote lung cancer development
Jinghan Shi, Fujun Yang, Nanfeng Zhou, Yan Jiang, Yanfeng Zhao, Junjie Zhu, Arsela Prelaj, Jyoti Malhotra, Nicola Normanno, Elisa Danese, Andrés F. Cardona, Xuan Hong, Gening Jiang, Xiao Song
circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p
Yanting Dong, Tong Qiu, Yunpeng Xuan, Ao Liu, Xiao Sun, Zhangfeng Huang, Wenhao Su, Wenxing Du, Tianxiang Yun, Yang Wo, Alfons Navarro, Wenjie Jiao
The effectiveness of three-dimensional reconstruction in the localization of multiple nodules in lung specimens: a prospective cohort study
Ying Ji, Tao Zhang, Lin Yang, Xin Wang, Linlin Qi, Fengwei Tan, Jean H. T. Daemen, Erik R. de Loos, Bin Qiu, Shugeng Gao
A signature of estimate-stromal-immune score-based genes associated with the prognosis of lung adenocarcinoma
Qianli Ma, Yang Chen, Fei Xiao, Yang Hao, Zhiyi Song, Jin Zhang, Katsuhiro Okuda, Sang-Won Um, Mario Silva, Yoshihisa Shimada, Chaozeng Si, Chaoyang Liang
Increased detection of circulating tumor DNA by short fragment enrichment
Yang Liu, Yangyang Liu, Yingying Wang, Lei Li, Wenjun Yao, Yingnan Song, Bing Liu, Weihuang Chen, Mariacarmela Santarpia, Elisabetta Rossi, Rita Zamarchi, Zhe Wang, Qiming Wang, Gang Cheng
High discrepancy in thrombotic events in non-small cell lung cancer patients with different genomic alterations
Yiwei Liu, Wanying Wang, Fengying Wu, Guanghui Gao, Jian Xu, Xuefei Li, Chao Zhao, Shuo Yang, Shiqi Mao, Yingying Pan, Keyi Jia, Chuchu Shao, Bin Chen, Shengxiang Ren, Caicun Zhou
Concomitant mutation status of ALK-rearranged non-small cell lung cancers and its prognostic impact on patients treated with crizotinib
Jingjing Li, Bin Zhang, Yu Zhang, Feng Xu, Zhenfa Zhang, Lin Shao, Chunhe Yan, Paola Ulivi, Marc G. Denis, Petros Christopoulos, Vincent Thomas de Montpréville, Eric H. Bernicker, Anthonie J. van der Wekken, Changli Wang, Dongsheng Yue

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article

Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study
Luka Brcic, Thomas Klikovits, Zsolt Megyesfalvi, Berta Mosleh, Katharina Sinn, Richard Hritcu, Viktoria Laszlo, Tanja Cufer, Ales Rozman, Izidor Kern, Katja Mohorcic, Marko Jakopovic, Miroslav Samarzija, Sven Seiwerth, Vitezslav Kolek, Ondřej Fischer, Petr Jakubec, Jozef Škarda, Balazs Gieszer, Balazs Hegedus, Janos Fillinger, Ferenc Renyi-Vamos, Anna Buder, Agnes Bilecz, Walter Berger, Michael Grusch, Konrad Hoetzenecker, Walter Klepetko, Mir Alireza Hoda, Martin Filipits, Balazs Dome
EPAC-lung: European pooled analysis of the prognostic value of circulating tumour cells in small cell lung cancer
Victoria Foy, Colin R. Lindsay, Alexandra Carmel, Fabiola Fernandez-Gutierrez, Matthew G. Krebs, Lynsey Priest, Mathew Carter, Harry J. M. Groen, T. Jeroen. N. Hiltermann, Antonella de Luca, Francoise Farace, Benjamin Besse, Leon Terstappen, Elisabetta Rossi, Alessandro Morabito, Francesco Perrone, Andrew Renehan, Corinne Faivre-Finn, Nicola Normanno, Caroline Dive, Fiona Blackhall, Stefan Michiels
Spanish Lung Cancer Group SCAT trial: surgical audit to lymph node assessment based on IASLC recommendations
José Ramón Jarabo Sarceda, Sergio Bolufer Nadal, Roberto Mongil Poce, Pedro López de Castro, Ramón Moreno Balsalobre, Juan Carlos Peñalver Cuesta, Raul Embún Flor, Joaquín Pac Ferrer, Francisco Javier Algar Algar, Antonio Pablo Gámez García, Marcelo F. Jiménez, Jesús Gabriel Sales-Badía, Eva Pereira, Bartomeu Massuti, Mariano Provencio, Florentino Hernando Trancho
Is flexible bronchoscopy necessary in the preoperative workup of patients with peripheral cT1N0 subsolid lung cancer? A prospective multi-center cohort study
Ting Ye, Zongwei Chen, Dongchun Ma, Sufeng Chen, Guozhan Xia, Yiliang Zhang, Hang Li, Yang Zhang, Xiaoyang Luo, Longsheng Miao, Longfei Ma, Yihua Sun, Yunjian Pan, Hong Hu, Yawei Zhang, Jiaqing Xiang, Longlong Shao, Haoxuan Wu, Bin Li, Qingyuan Huang, Xiao Ma, Difan Zheng, Shanbo Zheng, Chongze Yuan, Tao Yu, Yunyun Lu, Yuan Li, Qiao Li, Yajia Gu, Shengping Wang, Di Ge, Jie Gu, Feng Zhu, Jingshun Zhang, Fudong Wang, Yuan Weng, Chunyi Jia, Shilei Liu, Wenqun Xing, Kaihong Lin, Shaoqing Tang, Bin Qian, Michael Hsin, Haiquan Chen
Conventional and semi-automatic histopathological analysis of tumor cell content for multigene sequencing of lung adenocarcinoma
Daniel Kazdal, Eugen Rempel, Cristiano Oliveira, Michael Allgäuer, Alexander Harms, Kerstin Singer, Elke Kohlwes, Steffen Ormanns, Ludger Fink, Jörg Kriegsmann, Michael Leichsenring, Katharina Kriegsmann, Fabian Stögbauer, Luca Tavernar, Jonas Leichsenring, Anna-Lena Volckmar, Rémi Longuespée, Hauke Winter, Martin Eichhorn, Claus Peter Heußel, Felix Herth, Petros Christopoulos, Martin Reck, Thomas Muley, Wilko Weichert, Jan Budczies, Michael Thomas, Solange Peters, Arne Warth, Peter Schirmacher, Albrecht Stenzinger, Mark Kriegsmann

Review Article


Editorial


Case Report