Hunting for transcription factors: STAT3 decoy in non-small cell lung cancer

Joseph Carmicheal, Sukhwinder Kaur, Surinder K. Batra, Apar Kishor Ganti


Non-small cell lung cancer (NSCLC) is by far the most common type of lung cancer and accounts for 84% of all cases. The majority of these patients present at advanced stages that are incurable and have >90% 5-year mortality rate (1). The cellular origin is of unknown etiology and rapidly becomes an incredibly heterogeneous disease containing myriad mutations and genetic alterations (2).