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Original Article

Comparison between closed pleural biopsy and medical thoracoscopy for the diagnosis of undiagnosed exudative pleural effusions: a systematic review and meta-analysis
Yuqing Wei, Kaikai Shen, Tangfeng Lv, Hongbing Liu, Zimu Wang, Juan Wu, He Zhang, Sara Colella, Fu-Zong Wu, Michael T. Milano, Ping Zhan, Yong Song, Zhiwei Lu, written on behalf of AME Lung Cancer Collaborative Group
Open-label, multicenter, randomized phase II study on docetaxel plus bevacizumab or pemetrexed plus bevacizumab for treatment of elderly (aged ≥75 years) patients with previously untreated advanced non-squamous non-small cell lung cancer: TORG1323
Toshiyuki Kozuki, Naoyuki Nogami, Osamu Hataji, Yoshio Tsunezuka, Nobuhiko Seki, Toshiyuki Harada, Nobukazu Fujimoto, Akihiro Bessho, Kei Takamura, Kazuhisa Takahashi, Miyako Satouchi, Terufumi Kato, Takehito Shukuya, Natsumi Yamashita, Hiroaki Okamoto, Tetsu Shinkai, Thoracic Oncology Research Group
EGFR mutation genotypes affect efficacy and resistance mechanisms of osimertinib in T790M-positive NSCLC patients
Qiufan Zheng, Yan Huang, Hongyun Zhao, Yunpeng Yang, Shaodong Hong, Xue Hou, Yuanyuan Zhao, Yuxiang Ma, Ting Zhou, Yaxiong Zhang, Wenfeng Fang, Li Zhang
Determining the invasiveness of pure ground-glass nodules using dual-energy spectral computed tomography
Ye Yu, Jie-Jun Cheng, Jian-Ying Li, Ying Zhang, Liao-Yi Lin, Feng Zhang, Jian-Rong Xu, Xiao-Jing Zhao, Hua-Wei Wu
The prevalence and prognostic significance of estrogen receptor beta expression in non-small cell lung cancer
Emeka K. Enwere, Michelle L. Dean, Haocheng Li, Adrijana D’Silva, D. Gwyn Bebb
Artificial intelligence and lung cancer treatment decision: agreement with recommendation of multidisciplinary tumor board
Min-Seok Kim, Ha-Young Park, Bo-Gun Kho, Cheol-Kyu Park, In-Jae Oh, Young-Chul Kim, Seok Kim, Ju-Sik Yun, Sang-Yun Song, Kook-Joo Na, Jae-Uk Jeong, Mee Sun Yoon, Sung-Ja Ahn, Su Woong Yoo, Sae-Ryung Kang, Seong Young Kwon, Hee-Seung Bom, Woo-Youl Jang, In-Young Kim, Jong-Eun Lee, Won-Gi Jeong, Yun-Hyeon Kim, Taebum Lee, Yoo-Duk Choi
18F-FDG PET/CT total lesion glycolysis is associated with circulating tumor cell counts in patients with stage I to IIIA non-small cell lung cancer
Diego M. Avella, Yariswamy Manjunath, Amolak Singh, Chelsea B. Deroche, Eric T. Kimchi, Kevin F. Staveley-O’Carroll, Jonathan B. Mitchem, Eric Kwon, Guangfu Li, Jussuf T. Kaifi
Role of chest radiographs in early lung cancer detection
Junghyun Kim, Kwan Hyoung Kim
ctDNA analysis reveals different molecular patterns upon disease progression in patients treated with osimertinib
Atocha Romero, Roberto Serna-Blasco, Cristina Alfaro, Estela Sánchez-Herrero, Miguel Barquín, María Carmen Turpin, Sofía Chico, Sandra Sanz-Moreno, Alejandro Rodrigez-Festa, Raquel Laza-Briviesca, Alberto Cruz-Bermudez, Virginia Calvo, Ana Royuela, Mariano Provencio
Maximum standardized uptake value of primary tumor (SUVmax_PT) and horizontal range between two most distant PET-positive lymph nodes predict patient outcome in inoperable stage III NSCLC patients after chemoradiotherapy
Olarn Roengvoraphoj, Lukas Käsmann, Chukwuka Eze, Julian Taugner, Arteda Gjika, Amanda Tufman, Indrawati Hadi, Minglun Li, Erik Mille, Kathrin Gennen, Claus Belka, Farkhad Manapov
Predicting EGFR mutation subtypes in lung adenocarcinoma using 18F-FDG PET/CT radiomic features
Qiufang Liu, Dazhen Sun, Nan Li, Jinman Kim, Dagan Feng, Gang Huang, Lisheng Wang, Shaoli Song
18F-fluorodeoxyglucose positron emission tomography/computed tomography-based radiomic features for prediction of epidermal growth factor receptor mutation status and prognosis in patients with lung adenocarcinoma
Bin Yang, Heng-Shan Ji, Chang-Sheng Zhou, Hao Dong, Lu Ma, Ying-Qian Ge, Chao-Hui Zhu, Jia-He Tian, Long-Jiang Zhang, Hong Zhu, Guang-Ming Lu
Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival
Danwen Qian, Hongliang Liu, Lingling Zhao, Xiaomeng Wang, Sheng Luo, Patricia G. Moorman, Edward F. Patz Jr, Li Su, Sipeng Shen, David C. Christiani, Qingyi Wei
Large nest micropapillary pattern of lung adenocarcinoma has poorer prognosis than typical floret pattern: analysis of 1,062 resected tumors
Kyoko Kondo, Akihiko Yoshizawa, Naoki Nakajima, Shinji Sumiyoshi, Yuki Teramoto, Mariyo Rokutan-Kurata, Makoto Sonobe, Toshi Menju, Hiroshi Date, Hironori Haga
Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis
Tobias Raphael Overbeck, Dana Alina Cron, Katja Schmitz, Achim Rittmeyer, Wolfgang Körber, Sara Hugo, Juliane Schnalke, Laura Lukat, Tabea Hugo, Marc Hinterthaner, Kirsten Reuter-Jessen, Tessa Rosenthal, Joachim Moecks, Annalen Bleckmann, Hans-Ulrich Schildhaus
Integrating clinical and biological prognostic biomarkers in patients with advanced NSCLC treated with immunotherapy: the DEMo score system
Arsela Prelaj, Claudia Proto, Giuseppe Lo Russo, Diego Signorelli, Roberto Ferrara, Mavis Mensah, Giulia Galli, Alessandro De Toma, Giuseppe Viscardi, Marta Brambilla, Riccardo Lobefaro, Benedetta Trevisan, Francesco Trovò, Valter Torri, Gabriella Sozzi, Marina Chiara Garassino, Mattia Boeri
Molecular gene mutation profiles, TMB and the impact of prognosis in Caucasians and east Asian patients with lung adenocarcinoma
Weiquan Gu, Na Wang, Weiguang Gu, Yuan Qiu, Hua Zhang, Jianmiao Liang, Tongfei Zhou, Liheng Ma, Weijing Cai, Weineng Feng, Likun Chen
Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma
Natasha K. Brockwell, Muhammad Alamgeer, Beena Kumar, Gareth Rivalland, Thomas John, Belinda S. Parker
The contribution of hereditary cancer-related germline mutations to lung cancer susceptibility
Mengyuan Liu, Xinyi Liu, Peisu Suo, Yuan Gong, Baolin Qu, Xiumei Peng, Wenhua Xiao, Yuemin Li, Yan Chen, Zhen Zeng, Yinying Lu, Tanxiao Huang, Yingshen Zhao, Ming Liu, Lifeng Li, Yaru Chen, Yanqing Zhou, Guifeng Liu, Jianfei Yao, Shifu Chen, Lele Song
Increased number of subclones in lung squamous cell carcinoma elicits overexpression of immune related genes
Myung Jin Song, Sang Hoon Lee, Eun Young Kim, Yoon Soo Chang
Integrated analysis of optical mapping and whole-genome sequencing reveals intratumoral genetic heterogeneity in metastatic lung squamous cell carcinoma
Yizhou Peng, Chongze Yuan, Xiaoting Tao, Yue Zhao, Xingxin Yao, Lingdun Zhuge, Jianwei Huang, Qiang Zheng, Yue Zhang, Hui Hong, Haiquan Chen, Yihua Sun
Predicting brain metastasis in early stage non-small cell lung cancer patients by gene expression profiling
Iris Kamer, Yael Steuerman, Inbal Daniel-Meshulam, Gili Perry, Shai Izraeli, Marina Perelman, Nir Golan, David Simansky, Iris Barshack, Alon Ben Nun, Teodor Gottfried, Amir Onn, Irit Gat-Viks, Jair Bar
Characterization of the lung microbiome and exploration of potential bacterial biomarkers for lung cancer
Chen Cheng, Zhifeng Wang, Jingqiao Wang, Chao Ding, Chuang Sun, Pingli Liu, Xiaoqiang Xu, Yanan Liu, Bi Chen, Bing Gu
Bioengineered carina reconstruction using In-Vivo Bioreactor technique in human: proof of concept study
Yuanyuan Xu, Zhiyi Guo, Ruijun Liu, Hongwu Wang, Sheng Wang, Walter Weder, Yingen Pan, Jingxiang Wu, Heng Zhao, Qingquan Luo, Qiang Tan
The CT appearance pattern of radiation-induced lung injury and tumor recurrence after stereotactic body radiation therapy in early stage non-small cell lung cancer
Qian Li, Yu Liu, Bin Su, Hongguang Zhao, Qingren Lin, Yaoyao Zhu, Lingnan Zhang, Denghu Weng, Xiaomei Gong, Xiaojiang Sun, Yaping Xu
Development and validation of a preoperative noninvasive predictive model based on circular tumor DNA for lymph node metastasis in resectable non-small cell lung cancer
Rusi Zhang, Xuewen Zhang, Zirui Huang, Fang Wang, Yongbin Lin, Yingsheng Wen, Li Liu, Jinbo Li, Xinyi Liu, Wenzhuan Xie, Mengli Huang, Gongming Wang, Longjun Yang, Dechang Zhao, Xiangyang Yu, Kexing Xi, Weidong Wang, Ling Cai, Lanjun Zhang
PRRX1 isoform PRRX1A regulates the stemness phenotype and epithelial-mesenchymal transition (EMT) of cancer stem-like cells (CSCs) derived from non-small cell lung cancer (NSCLC)
Lei Sun, Tao Han, Xinyu Zhang, Xiangli Liu, Peiwen Li, Mingrui Shao, Siyuan Dong, Wenya Li
The effect of combining Endostar with radiotherapy on blood vessels, tumor-associated macrophages, and T cells in brain metastases of Lewis lung cancer
Ling Peng, Ying Wang, Shihong Fei, Chunhua Wei, Fan Tong, Gang Wu, Hong Ma, Xiaorong Dong

Review Article

Mechanisms of drugs-resistance in small cell lung cancer: DNA-related, RNA-related, apoptosis-related, drug accumulation and metabolism procedure
Peixin Chen, Peng Kuang, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Lingyun Ye, Feng Yu, Yayi He, Caicun Zhou

Case Report

Emergence of a HER2-amplified clone during disease progression in an ALK-rearranged NSCLC patient treated with ALK-inhibitors: a case report
Roberta Minari, Letizia Gnetti, Costanza Annamaria Lagrasta, Anna Squadrilli, Paola Bordi, Cinzia Azzoni, Lorena Bottarelli, Agnese Cosenza, Leonarda Ferri, Giuseppe Caruso, Enrico Maria Silini, Marcello Tiseo
Clinical impact of the lung tissue transcriptome in a teenager with multifocal invasive mucinous adenocarcinoma—a case report
Emma Di Carlo, Giuseppe Cipollone, Felice Mucilli, Carlo Sorrentino
Immuno-based therapeutic strategies for initial unresectable locally advanced non-small cell lung cancer: a case report
Long Jiang, Jia Huang, Chongwu Li, Yaofeng Shen, Yonglun Zhang, Shun Lu, Qingquan Luo

Letter to the Editor

cfDNA changes for monitoring of targeted therapy in a primary EGFR mutation lung adenocarcinoma
Qiong He, Xian Zhu, Xun Shi, Chen Lin, Yin Jin, Junrong Yan, Jiachen He, Xinmin Yu

Editorial on Selected Highlights of the 2019 Pulmonary Pathology Society Biennial Meeting1

Selected highlights of the 2019 Pulmonary Pathology Society Biennial Meeting
Sanja Dacic

Review Article on Selected Highlights of the 2019 Pulmonary Pathology Society Biennial Meeting1

Controversies and challenges in the histologic subtyping of lung adenocarcinoma
Kelly J. Butnor
Significance of tumor spread through air spaces (STAS) in lung cancer from the pathologist perspective
Mari Mino-Kenudson
Multiple faces of pulmonary large cell neuroendocrine carcinoma: update with a focus on practical approach to diagnosis
Marina K. Baine, Natasha Rekhtman
Lung cancer biomarker tests: the history and perspective in Japan
Noriko Motoi, Yasushi Yatabe
Lung cancer biomarker testing: perspective from Europe
Erik Thunnissen, Birgit Weynand, Dalma Udovicic-Gagula, Luka Brcic, Malgorzata Szolkowska, Paul Hofman, Silvana Smojver-Ježek, Sisko Anttila, Fiorella Calabrese, Izidor Kern, Birgit Skov, Sven Perner, Vibeke G. Dale, Zivka Eri, Alex Haragan, Diana Leonte, Lina Carvallo, Spasenja Savic Prince, Siobhan Nicholson, Irene Sansano, Ales Ryska
Immunocytochemistry of cytology specimens for predictive biomarkers in lung cancer
Sinchita Roy-Chowdhuri
Selected highlights of the 2019 Pulmonary Pathology Society Biennial Meeting: PD-L1 test harmonization studies
Sylvie Lantuejoul, Francesca Damiola, Julien Adam
Update on the pathologic diagnosis of malignant mesothelioma
Jefree J. Schulte, Aliya N. Husain
Clinical significance of histologic subtyping of malignant pleural mesothelioma
Luka Brcic, Izidor Kern
Integrative approach to cytologic and molecular diagnosis of malignant pleural mesothelioma
Anders Hjerpe, Sulaf Abd Own, Katalin Dobra

Disclosure:

1. The series “Selected Highlights of the 2019 Pulmonary Pathology Society Biennial Meeting” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Sanja Dacic served as the unpaid Guest Editor for the series.

Review Article

Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Bryan A. Chan, Brett G.M. Hughes
Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Global trends of lung cancer mortality and smoking prevalence
Farhad Islami, Lindsey A. Torre, Ahmedin Jemal
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Tackling ALK in non-small cell lung cancer: the role of novel inhibitors
Francesco Facchinetti, Marcello Tiseo, Massimo Di Maio, Paolo Graziano, Emilio Bria, Giulio Rossi, Silvia Novello
Circulating tumor cells versus circulating tumor DNA in lung cancer—which one will win?
Silvia Calabuig-Fariñas, Eloísa Jantus-Lewintre, Alejandro Herreros-Pomares, Carlos Camps

Review Article on Lung Cancer Diagnostics and Treatments 2015: A Renaissance of Patient Care

Immune checkpoint inhibitors in clinical practice: update on management of immune-related toxicities
Jeryl Villadolid, Asim Amin

Original Article

Prognostic value of Twist in lung cancer: systematic review and meta-analysis
Junli Zeng, Ping Zhan, Guannan Wu, Wen Yang, Wenjun Liang, Tangfeng Lv, Yong Song
BRAF mutations in non-small cell lung cancer
Peter P. Luk, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina Selinger, Trina Lum, Steven Kao, Sandra A. O’Toole, Wendy A. Cooper
The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Shu Wang, Bing Yu, Chiu Chin Ng, Belinda Mercorella, Christina I. Selinger, Sandra A. O’Toole, Wendy A. Cooper
Itraconazole can inhibit malignant pleural effusion by suppressing lymphangiogenesis in mice
Yunfen Wang, Yanwen Yao, Hongbin Liu, Xingqun Ma, Tangfeng Lv, Dongmei Yuan, Xinwu Xiao, Jie Yin, Yong Song
Ratio of maximum standardized uptake value to primary tumor size is a prognostic factor in patients with advanced non-small cell lung cancer
Fangfang Chen, Yanwen Yao, Chunyan Ma, Xingqun Ma, Zhaofeng Wang, Tangfeng Lv, Xinwu Xiao, Jie Yin, Yong Song
Advanced proton beam dosimetry part II: Monte Carlo vs. pencil beam-based planning for lung cancer
Dominic Maes, Jatinder Saini, Jing Zeng, Ramesh Rengan, Tony Wong, Stephen R. Bowen
The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants
Randa A. El-Zein, Carol J. Etzel, Reginald F. Munden
The use of TCP based EUD to rank and compare lung radiotherapy plans: in-silico study to evaluate the correlation between TCP with physical quality indices
Abdulhamid Chaikh, Jacques Balosso

Review Article

Beyond ALK-RET, ROS1 and other oncogene fusions in lung cancer
Takashi Kohno, Takashi Nakaoku, Koji Tsuta, Katsuya Tsuchihara, Shingo Matsumoto, Kiyotaka Yoh, Koichi Goto
Overview of clinicopathologic features of ALK-rearranged lung adenocarcinoma and current diagnostic testing for ALK rearrangement
Hyojin Kim, Jin-Haeng Chung
Neoadjuvant and adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy for lung cancer
Haoran Zhai, Wenzhao Zhong, Xuening Yang, Yi-Long Wu
Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations—a review
Erin L. Stewart, Samuel Zhixing Tan, Geoffrey Liu, Ming-Sound Tsao
Clinical trials for lung cancer in China
Fei-Yu Niu, Wen-Zhao Zhong, Qing Zhou, Yi-Long Wu
Recurrence after surgery in patients with NSCLC
Hidetaka Uramoto, Fumihiro Tanaka
Prognostic markers in lung cancer: is it ready for prime time?
Chang-Qi Zhu, Ming-Sound Tsao
Potential biomarkers for lung cancer screening
Gabriella Sozzi, Mattia Boeri
Particle therapy in non-small cell lung cancer
Zhongxing Liao, Charles B. Simone II
Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Ryan Clay, Srinivasan Rajagopalan, Ronald Karwoski, Fabien Maldonado, Tobias Peikert, Brian Bartholmai
Immunotherapy and radiation therapy for operable early stage and locally advanced non-small cell lung cancer
Neil K. Taunk, Andreas Rimner, Melissa Culligan, Joseph S. Friedberg, Julie Brahmer, Jamie Chaft
Combining immunotherapy and radiation therapy for small cell lung cancer and thymic tumors
Suchit H. Patel, Andreas Rimner, Roger B. Cohen
Intraoperative near-infrared imaging of mesothelioma
Gregory Thomas Kennedy, Andrew Newton, Jarrod Predina, Sunil Singhal
BAP1, a tumor suppressor gene driving malignant mesothelioma
Mitchell Cheung, Joseph R. Testa
Uncovering the immune tumor microenvironment in non-small cell lung cancer to understand response rates to checkpoint blockade and radiation
Jonathan E. Schoenhals, Steven N. Seyedin, Clark Anderson, Eric D. Brooks, Yun R. Li, Ahmed I. Younes, Sharareh Niknam, Ailin Li, Hampartsoum B. Barsoumian, Maria Angelica Cortez, James W. Welsh
Diagnostic and prognostic biomarkers for malignant mesothelioma: an update
Zhongjian Chen, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, Haining Yang
Immunotherapy for malignant pleural mesothelioma: current status and future directions
Jordan Dozier, Hua Zheng, Prasad S. Adusumilli
Biology and clinical significance of circulating tumor cell subpopulations in lung cancer
Linda O’Flaherty, Harriet Wikman, Klaus Pantel
Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer—ready for prime-time?
Emma Pailler, Vincent Faugeroux, Marianne Oulhen, Cyril Catelain, Françoise Farace
Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer
Sumitra Mohan, Francesca Chemi, Ged Brady
Biophysical technologies for understanding circulating tumor cell biology and metastasis
Derrick W. Su, Jorge Nieva
Clinical utility of circulating tumor cells in patients with non-small-cell lung cancer
Marianna Gallo, Antonella De Luca, Monica Rosaria Maiello, Amelia D’Alessio, Claudia Esposito, Nicoletta Chicchinelli, Laura Forgione, Maria Carmela Piccirillo, Gaetano Rocco, Alessandro Morabito, Gerardo Botti, Nicola Normanno
Integrating immunotherapy into chemoradiation regimens for medically inoperable locally advanced non-small cell lung cancer
Salma K. Jabbour, Abigail T. Berman, Charles B. Simone II

Systematic Review and Meta-analysis

Association of the metformin with the risk of lung cancer: a meta-analysis
Li Wang, Yong Song, Guan-Nan Wu, Dong-Mei Yuan

Editorials

Dulanermin in cancer therapy: Still much to do
Cristina Quintavalle, Gerolama Condorelli

Review Articles

EGFR molecular testing in African-American non-small cell lung cancer patients - a review of discrepant data
Bradley T. Clifford, Pingfu Fu, Nathan A. Pennell, Balazs Halmos, Rom S. Leidner
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung
Pedro Mendez, Jose Luis Ramirez
Role of HGF/MET axis in resistance of lung cancer to contemporary management
Kanwal Pratap Singh Raghav, Ana Maria Gonzalez-Angulo, George R. Blumenschein Jr
Circulating soluble intercellular adhesion Molecule-1 in lung cancer: a systematic review
Xiaoling Gu, Chunyan Ma, Dongmei Yuan, Yong Song

Onartuzumab plus erlotinib

Targeting MET in NSCLC: looking for a needle in a haystack
Lorenza Landi, Federico Cappuzzo

Review Article on Update on Pathology and Predictive Biomarkers of Lung Cancer

Biology of invasive mucinous adenocarcinoma of the lung
Yoon Jin Cha, Hyo Sup Shim
Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Mari Mino- Kenudson

Below are the latest Translational Lung Cancer Research articles published online ahead of print publication.

Original Article


Review Article


Editorial


Review Article


Letter to the Editor


Case Report


Brief Report


Editorial Commentary



Consensus