Optimizing immobilization, margins, and imaging for lung stereotactic body radiation therapy

Jason K. Molitoris, Tejan Diwanji, James W. Snider III, Sina Mossahebi, Santanu Samanta, Nasarachi Onyeuku, Pranshu Mohindra, J. Isabelle Choi, Charles B. Simone II


The simultaneous advancement of technologies for the delivery of precisely targeted radiation therapy and the paradigm shift to substantial hypofractionation have led to significant improvements in the treatment of early stage non-small cell lung cancer (ES-NSCLC). Stereotactic body radiation therapy (SBRT) has become a well-established option for the treatment of ES-NSCLC and is now becoming widely available within the radiation oncology community. Implementation of this technique, however, requires highly accurate target delineation, thorough evaluation of tumor motion, and improved on-board imaging at the time of treatment for patient alignment, each of which is critical for successful tumor control and mitigation of risks to normal tissues. In this article, we review updates and issues related to immobilization and image guidance for SBRT in the treatment of ES-NSCLC.