Lung neuroendocrine tumors: a new addition to the evolving list of spread through air spaces

Hironori Uruga, Mari Mino-Kenudson


Air-filled spaces are a notable characteristic of the lung. When a cancer develops in the lung, it is often surrounded by air spaces; thus, there is the possibility that cancer cells spread thorough air spaces. In fact, Kodama and colleagues presented a lung cancer case with multifocal “aerogenous” spread in 1980 and ultrastructurally studied the nature of detached fragments (1).