P36. The prognostic potential of circulating and tissue activin A level in malignant pleural mesothelioma
CELCC 2014 Abstracts

P36. The prognostic potential of circulating and tissue activin A level in malignant pleural mesothelioma

Yawen Dong1, Mir Alireza Hoda1, Karin Schelch2, Anita Rozsas1, Viktoria Laszlo1, Balazs Dome1, Michael Grusch2, Walter Berger2, Walter Klepetko1, Balazs Hegedus1

1Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Vienna, Austria; 2Institute of Cancer Research, Department of Medicine I, Vienna, Austria


Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy characterized by poor outcome and there is a lack of prognostic biomarkers to estimate prognosis. Previously we have shown that suppression of activin A can interfere with MPM tumor growth. In the current study, we compare the circulating and tissue expression level of activin A as a prognostic biomarker in MPM.

Methods: In a cohort of 53 MPM patients, plasma samples were collected between 2010 and 2014. Controls consisted of age-matched healthy individuals (n=46) and patients with pleuritis or pleural fibrosis (n=16). Circulating activin A was measured by ELISA and correlated to clinicopathological data. Furthermore, activin A expression in the tumor tissue was semiquantitatively measured by immunohistochemistry in 24 patients.

Results: Plasma activin A level was significantly elevated in MPM patients (n=53, 843±122 pg/mL) when compared to healthy controls (452±144 pg/mL, P=0.0039). Non-malignant pleuritis or pleural fibrosis patients only showed a modest, non-significant increase (625±95 pg/mL, P=0.093). Circulating activin A levels were slightly increased in cases with non-epitheloid morphology (n=16, 1101±183) when compared to epithelioid (n=37, 732±153 pg/mL, P=0.13). MPM patients with below median activin A concentrations had a modestly and non-significantly longer overall survival when compared to the high activin A level patients (469 vs. 271 days, P=0.4751). Interestingly, there was no correlation between circulating and tissue expression level of activin A in 17 patients where both parameters could have been analyzed.

Conclusions: Our findings suggest that the measurement of circulating activin A may support the diagnosis and prognosis of MPM but additional patient cohorts need to be analyzed to establish the diagnostic and prognostic value of this non-invasive biomarker.

Keywords: Mesothelioma; activin A


doi: 10.3978/j.issn.2218-6751.2014.AB048


Cite this article as: Dong Y, Hoda MA, Schelch K, Rozsas A, Laszlo V, Dome B, Grusch M, Berger W, Klepetko W, Hegedus B. The prognostic potential of circulating and tissue activin A level in malignant pleural mesothelioma. Transl Lung Cancer Res 2014;3(5):AB048. doi: 10.3978/j.issn.2218-6751.2014.AB048

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