Vol 9, No 5 (October 2020): Translational Lung Cancer Research

Original Article

Nivolumab in pre-treated advanced non-small cell lung cancer: long term follow up data from the Dutch expanded access program and routine clinical care
Robert D. Schouten, Lucie Egberink, Mirte Muller, Cornedine J. De Gooijer, Erik van Werkhoven, Michel M. van den Heuvel, Paul Baas
The different central nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer
Hyun Ae Jung, Sook Young Woo, Se-Hoon Lee, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Jong-Mu Sun
KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples
Herbert Ho-Fung Loong, Nan Du, Chunyan Cheng, Hanqing Lin, Jian Guo, Gen Lin, Mingjiang Li, Tao Jiang, Zhihua Shi, Yanzhi Cui, Xianfeng Jin, Jicheng Yao, Yutong Xing, Ming Yao, Kai Wang, Tony S. K. Mok, Lunxu Liu
The effect of PD-L1 categories-directed pembrolizumab plus chemotherapy for newly diagnosed metastatic non-small-cell lung cancer: a cost-effectiveness analysis
Bin Wu, Shun Lu
Treatments for combined small cell lung cancer patients
Jiaxi He, Songhui Xu, Hui Pan, Shuben Li, Jianxing He
Ex vivo culture of circulating tumour cells derived from non-small cell lung cancer
Joanna Kapeleris, Arutha Kulasinghe, Majid Ebrahimi Warkiani, Connor Oleary, Ian Vela, Paul Leo, Peter Sternes, Kenneth O’Byrne, Chamindie Punyadeera
SRC and PIM1 as potential co-targets to overcome resistance in MET deregulated non-small cell lung cancer
Ilaria Attili, Laura Bonanno, Niki Karachaliou, Jillian Wilhelmina Paulina Bracht, Jordi Berenguer, Carles Codony-Servat, Jordi Codony-Servat, Erika Aldeguer, Ana Gimenez-Capitan, Alessandro Dal Maso, Matteo Fassan, Imane Chaib, Miguel Angel Molina-Vila, Antonio Passaro, Filippo de Marinis, Giulia Pasello, Valentina Guarneri, Pier Franco Conte, Rafael Rosell
Significant diaphragm elevation suggestive of phrenic nerve injury after thoracoscopic lobectomy for lung cancer: an underestimated problem
Luigi Ventura, Weigang Zhao, Tangbing Chen, Zhexin Wang, Jian Feng, Zhitao Gu, Chunyu Ji, Wentao Fang
Interactions between the enhanced recovery after surgery pathway and risk factors for lung infections after pulmonary malignancy operation
Xianfei Zhang, Runsen Jin, Yuyan Zheng, Dingpei Han, Kai Chen, Jian Li, Hecheng Li
Establishment and validation of a mathematical diagnosis model to distinguish benign pulmonary nodules from early non-small cell lung cancer in Chinese people
Qiang Wei, Weizhen Fang, Xi Chen, Zhongzhen Yuan, Yumei Du, Yanbin Chang, Yonghong Wang, Shulin Chen
Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with EGFR exon 20 insertion mutation: a multicenter study
Chun-Wei Xu, Wen-Xian Wang, Dong Wang, Qi-Ming Wang, Xing-Xiang Pu, You-Cai Zhu, Jian-Hui Huang, Zong-Yang Yu, Zhao-Lei Cui, Xiao-Hui Chen, Jin-Luan Li, Yong Fang, Hong Wang, Wu Zhuang, Shi-Jie Lan, Xin Cai, Yin-Bin Zhang, Wen-Bin Gao, Li-Ping Wang, Ke-Lin She, Chuang-Zhou Rao, Yue-Fen Zhou, Mei-Yu Fang, Li-Yun Miao, Lei Lei, Tang-Feng Lv, Yong Song, on behalf of AME Lung Cancer Collaborative Group
Stereotactic body radiation therapy for empirically treated hypermetabolic lung lesions: a single-institutional experience identifying the Charlson score as a key prognostic factor
Roman O. Kowalchuk, Michael R. Waters, Sujith Baliga, K. Martin Richardson, Kelly M. Spencer, James M. Larner, Charles R. Kersh
Longitudinal multi-gene panel assessment of circulating tumor DNA revealed tumor burden and molecular characteristics along treatment course of non-small cell lung cancer
Gloria Y. F. Ho, Tao Wang, Hoi-Hin Kwok, Rehana Rasul, Rita Peila, Maria Guzman, Mary S. M. Ip, David C. L. Lam
ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma
Chaoyang Liang, Xiaowei Wang, Zhenrong Zhang, Fei Xiao, Hongxiang Feng, Qianli Ma, Jingjing Huang, Guangliang Qiang, Dingrong Zhong, Deruo Liu
Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells
Michelle Simone Clement, Kristine Raaby Gammelgaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Prognostic implications of preoperative versus postoperative circulating tumor DNA in surgically resected lung cancer patients: a pilot study
Shuta Ohara, Kenichi Suda, Kazuko Sakai, Masaya Nishino, Masato Chiba, Masaki Shimoji, Toshiki Takemoto, Toshio Fujino, Takamasa Koga, Akira Hamada, Junichi Soh, Kazuto Nishio, Tetsuya Mitsudomi
How long is cessation of preoperative smoking required to improve postoperative survival of patients with pathological stage I non-small cell lung cancer?
Toshiyuki Shima, Tomonari Kinoshita, Mao Uematsu, Naomichi Sasaki, Yusuke Sugita, Reiko Shimizu, Masahiko Harada, Tsunekazu Hishima, Hirotoshi Horio
SMO mutations confer poor prognosis in malignant pleural mesothelioma
Diego Signorelli, Claudia Proto, Laura Botta, Annalisa Trama, Marcello Tiseo, Giulia Pasello, Giuseppe Lo Russo, Alessandra Fabbri, Martina Imbimbo, Adele Busico, Arsela Prelaj, Roberto Ferrara, Giulia Galli, Alessandro De Toma, Elena Tamborini, Ugo Pastorino, Filippo de Braud, Gemma Gatta, Marina Chiara Garassino, Monica Ganzinelli
Low T790M relative allele frequency indicates concurrent resistance mechanisms and poor responsiveness to osimertinib
Ye Wang, Yanqi He, Panwen Tian, Weiya Wang, Ke Wang, Shannon Chuai, Yalun Li, Shuang Zhao, Yu Wang, Weimin Li
A pilot study of the ultrathin cryoprobe in the diagnosis of peripheral pulmonary ground-glass opacity lesions
Simin Jiang, Xiaojun Liu, Junxiang Chen, Haifeng Ma, Fangfang Xie, Jiayuan Sun
Enumeration and molecular characterization of circulating tumor cells enriched by microcavity array from stage III non-small cell lung cancer patients
Evan N. Cohen, Gitanjali Jayachandran, Hui Gao, Wei Qiao, Suyu Liu, Jianzhong He, Yawei Qiao, Luyang Yao, Steven H. Lin, James M. Reuben
Is clinical target volume necessary?—a failure pattern analysis in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy using intensity-modulated radiotherapy technique
Liqing Zou, Li Chu, Fan Xia, Lijun Zhou, Xi Yang, Jianjiao Ni, Junchao Chen, Zhengfei Zhu
Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio associations with heart and body dose and their effects on patient outcomes in locally advanced non-small cell lung cancer treated with definitive radiotherapy
Wu-Yan Xia, Xue-Ru Zhu, Wen Feng, Jun Liu, Jia-Ming Wang, Chang-Xing Lv, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu

Study Protocol

GEMSTONE-301: a phase III clinical trial of CS1001 as consolidation therapy in patients with locally advanced/ unresectable (stage III) non-small cell lung cancer (NSCLC) who did not have disease progression after prior concurrent/sequential chemoradiotherapy
Qing Zhou, Ming Chen, Gang Wu, Jian-Hua Chang, Ou Jiang, Jiu-Wei Cui, Guang Han, Qin Lin, Jian Fang, Gong-Yan Chen, Yi-Long Wu
Evaluating the diagnostic accuracy of a ctDNA methylation classifier for incidental lung nodules: protocol for a prospective, observational, and multicenter clinical trial of 10,560 cases
Wenhua Liang, Dan Liu, Min Li, Wei Wang, Zheng Qin, Jian Zhang, Yong Zhang, Yang Hu, Hairong Bao, Yi Xiang, Bo Wang, Jing Wu, Jianyu Sun, Chengping Hu, Xianwei Ye, Xiangyan Zhang, Wei Xiao, Chunmei Yun, Dejun Sun, Wei Wang, Ning Chang, Yunhui Zhang, Jianping Zhao, Xin Zhang, Jinfu Xu, Di Wu, Xiaoju Liu, Yubiao Guo, Qichuan Zhang, Wei Zhang, Lan Yang, Zhanqing Li, Xiaoju Zhang, Baohui Han, Zhaohui Tong, Jianxing He, Jieming Qu, Jian-Bing Fan, Nanshan Zhong

Technical Note

Dynamic titanium prosthesis based on 3D-printed replica for chest wall resection and reconstruction
Jacopo Vannucci, Elisa Scarnecchia, Rossella Potenza, Silvia Ceccarelli, Donato Monopoli, Francesco Puma

Review Article

Optimizing current standard of care therapy for stage III non-small cell lung cancer
Vivek Verma, Steven H. Lin
A narrative review of toxicity of chemoradiation and immunotherapy for unresectable, locally advanced non-small cell lung cancer
Rahul N. Prasad, Terence M. Williams
Narrative review of the emerging role of molecular biomarkers in guiding the definitive management of unresectable non-small cell lung cancer
Eric K. Singhi, Carl M. Gay
Treatment of stage III non-small cell lung cancer in the era of immunotherapy: pathological complete response to neoadjuvant pembrolizumab and chemotherapy
Zhang-Ru Yang, Mi-Na Liu, Jia-Hua Yu, Yun-Hai Yang, Tian-Xiang Chen, Yu-Chen Han, Lei Zhu, Ji-Kai Zhao, Xiao-Long Fu, Xu-Wei Cai
A narrative review of lung cancer cytology in the times of coronavirus: what physicians should know
Pasquale Pisapia, Umberto Malapelle, Maria Salatiello, Rafael Rosell, Giancarlo Troncone
A narrative review of synergistic drug administration in unresectable locally advanced non-small cell lung cancer: current landscape and future prospects in the era of immunotherapy
Shuyan Li, Xiao Chu, Luxi Ye, Jianjiao Ni, Zhengfei Zhu
Radiotherapy for unresectable locally advanced non-small cell lung cancer: a narrative review of the current landscape and future prospects in the era of immunotherapy
Tiantian Guo, Liqing Zou, Jianjiao Ni, Xiao Chu, Zhengfei Zhu
A narrative review of biosimilars: a continued journey from the scientific evidence to practice implementation
Jorge J. García, Luis E. Raez, Daniel Rosas
Radiotherapy for non-small cell lung cancer in the immunotherapy era: the opportunity and challenge—a narrative review
Wu-Yan Xia, Wen Feng, Chen-Chen Zhang, Yu-Jia Shen, Qin Zhang, Wen Yu, Xu-Wei Cai, Xiao-Long Fu
Perspective on treatment for unresectable locally advanced non-small cell lung cancer with oncogene-driven mutation: a narrative review
Liyang Jiang, Xiangjiao Meng, Xianguang Zhao, Ligang Xing, Jinming Yu

Disclosure:

1. The series “New Developments in Lung Cancer Diagnosis and Pathological Patient Management Strategies” was commissioned by the Editorial office, Translational Lung Cancer Research without any sponsorship or funding. Helmut Popper served as the unpaid Guest Editor for the series.